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Biosynthetic study of FR-900848: unusual observation on polyketide biosynthesis that did not accept acetate as origin of acetyl-CoA
| Title: | Biosynthetic study of FR-900848: unusual observation on polyketide biosynthesis that did not accept acetate as origin of acetyl-CoA |
| Authors: | Watanabe, Hiroaki Browse this author | | Tokiwano, Tetsuo2 Browse this author | | Oikawa, Hideaki3 Browse this author →KAKEN DB |
| Authors(alt): | 常盤野, 哲生2 | | 及川, 英秋3 |
| Keywords: | FR-900848 | | Antifungal agent | | Biosynthesis | | Polyketide | | Polycyclopropane | | Aminonucleoside |
| Issue Date: | 27-Feb-2006 |
| Publisher: | Elsevier |
| Journal Title: | Tetrahedron Letters |
| Volume: | 47 |
| Issue: | 9 |
| Start Page: | 1399 |
| End Page: | 1402 |
| Publisher DOI: | 10.1016/j.tetlet.2005.12.091 |
| Abstract: | The biosynthetic pathway of a potent antifungal agent, FR-900848, has been examined by administration of several 13C-labeled precursors to Streptoverticillium fervens HP-891. Although none of the 13C-labeled acetate was incorporated into FR-900848, the labeling pattern of FR-900848 derived from d-[U-13C6]glucose revealed that the fatty acid backbone of FR-900848 has been biosynthesized via a polyketide pathway. These unusual results strongly show that the major pathway to provide acetyl-CoA in this microorganism is glycolysis. Feeding experiments with d-[U-13C6]glucose, [1,3-13C2]glycerol, and l-[Me-13C]methionine provided information on the biosynthetic origin of structurally unusual parts (polycyclopropane and aminonucleoside) in this antibiotic. |
| Relation: | http://www.sciencedirect.com/science/journal/00404039 |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/5813 |
| Appears in Collections: | 理学院・理学研究院 (Graduate School of Science / Faculty of Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 常盤野 哲生
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