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Biosynthetic study of FR-900848: unusual observation on polyketide biosynthesis that did not accept acetate as origin of acetyl-CoA

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Title: Biosynthetic study of FR-900848: unusual observation on polyketide biosynthesis that did not accept acetate as origin of acetyl-CoA
Authors: Watanabe, Hiroaki Browse this author
Tokiwano, Tetsuo2 Browse this author
Oikawa, Hideaki3 Browse this author →KAKEN DB
Authors(alt): 常盤野, 哲生2
及川, 英秋3
Keywords: FR-900848
Antifungal agent
Biosynthesis
Polyketide
Polycyclopropane
Aminonucleoside
Issue Date: 27-Feb-2006
Publisher: Elsevier
Journal Title: Tetrahedron Letters
Volume: 47
Issue: 9
Start Page: 1399
End Page: 1402
Publisher DOI: 10.1016/j.tetlet.2005.12.091
Abstract: The biosynthetic pathway of a potent antifungal agent, FR-900848, has been examined by administration of several 13C-labeled precursors to Streptoverticillium fervens HP-891. Although none of the 13C-labeled acetate was incorporated into FR-900848, the labeling pattern of FR-900848 derived from d-[U-13C6]glucose revealed that the fatty acid backbone of FR-900848 has been biosynthesized via a polyketide pathway. These unusual results strongly show that the major pathway to provide acetyl-CoA in this microorganism is glycolysis. Feeding experiments with d-[U-13C6]glucose, [1,3-13C2]glycerol, and l-[Me-13C]methionine provided information on the biosynthetic origin of structurally unusual parts (polycyclopropane and aminonucleoside) in this antibiotic.
Relation: http://www.sciencedirect.com/science/journal/00404039
Type: article (author version)
URI: http://hdl.handle.net/2115/5813
Appears in Collections:理学院・理学研究院 (Graduate School of Science / Faculty of Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 常盤野 哲生

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