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Non-linear pharmacodynamics in a non-viral gene delivery system: Positive non-linear relationship between dose and transfection efficiency

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タイトル: Non-linear pharmacodynamics in a non-viral gene delivery system: Positive non-linear relationship between dose and transfection efficiency
著者: Moriguchi, Rumiko 著作を一覧する
Kogure, Kentaro 著作を一覧する
Iwasa, Akitada 著作を一覧する
Akita, Hidetaka 著作を一覧する
Hideyoshi, Harashima 著作を一覧する
キーワード: non-viral gene delivery system
intracellular pharmacokinetics
pharmacodinamics
synergism
発行日: 2006年 2月
出版者: Elsevier B.V
誌名: Journal of Controlled Release
巻: 110
号: 3
開始ページ: 605
終了ページ: 609
出版社 DOI: 10.1016/j.jconrel.2005.10.021
抄録: A remarkable non-linearity was found between dose and transfection activities of non-viral gene delivery systems, such as a Lipofectamine/DNA complex and an octaarginine-modified multifunctional envelope-type nano device (R8-MEND). We measured the nuclear delivery of pDNA to distinguish the non-linearity in intracellular pharmacokinetics or pharmacodynamics after transfection with R8-MEND at different doses. A remarkable positive non-linearity was found in the pharmacodynamics when the dose was increased. Even dummy pDNA enhanced the efficiency of transcription and/or translation per pDNA in the nucleus, but empty liposomes did not. These results suggest the importance of controlled pharmacodynamics as well as the importance of intracellular pharmacokinetics for the rational design of non-viral gene delivery systems.
記述: http://www.elsevier.com/wps/find/journaldescription.cws_home/502690/description
資料タイプ: article (author version)
URI: http://hdl.handle.net/2115/5922
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 原島 秀吉

 

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