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Non-linear pharmacodynamics in a non-viral gene delivery system: Positive non-linear relationship between dose and transfection efficiency

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Title: Non-linear pharmacodynamics in a non-viral gene delivery system: Positive non-linear relationship between dose and transfection efficiency
Authors: Moriguchi, Rumiko Browse this author
Kogure, Kentaro Browse this author
Iwasa, Akitada Browse this author
Akita, Hidetaka Browse this author
Hideyoshi, Harashima5 Browse this author →KAKEN DB
Authors(alt): 原島, 秀吉5
Keywords: non-viral gene delivery system
intracellular pharmacokinetics
pharmacodinamics
synergism
Issue Date: Feb-2006
Publisher: Elsevier B.V
Journal Title: Journal of Controlled Release
Volume: 110
Issue: 3
Start Page: 605
End Page: 609
Publisher DOI: 10.1016/j.jconrel.2005.10.021
PMID: 16360229
Abstract: A remarkable non-linearity was found between dose and transfection activities of non-viral gene delivery systems, such as a Lipofectamine/DNA complex and an octaarginine-modified multifunctional envelope-type nano device (R8-MEND). We measured the nuclear delivery of pDNA to distinguish the non-linearity in intracellular pharmacokinetics or pharmacodynamics after transfection with R8-MEND at different doses. A remarkable positive non-linearity was found in the pharmacodynamics when the dose was increased. Even dummy pDNA enhanced the efficiency of transcription and/or translation per pDNA in the nucleus, but empty liposomes did not. These results suggest the importance of controlled pharmacodynamics as well as the importance of intracellular pharmacokinetics for the rational design of non-viral gene delivery systems.
Description: http://www.elsevier.com/wps/find/journaldescription.cws_home/502690/description
Type: article (author version)
URI: http://hdl.handle.net/2115/5922
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 原島 秀吉

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