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On the mechanisms for the conversion of ventricular fibrillation to tachycardia by perfusion with ruthenium red
| Title: | On the mechanisms for the conversion of ventricular fibrillation to tachycardia by perfusion with ruthenium red |
| Authors: | Kimura, Hiroyuki Browse this author | | Kawahara, Koichi2 Browse this author →KAKEN DB | | Yamauchi, Yoshiko Browse this author →KAKEN DB | | Miyaki, Jyunichi Browse this author |
| Authors(alt): | 河原, 剛一2 |
| Keywords: | Ventricular fibrillation | | Ventricular tachycardia | | Action potential duration | | Mitochondria | | Ruthenium red | | Restitution curve |
| Issue Date: | Oct-2005 |
| Publisher: | Elsevier Inc. |
| Journal Title: | Journal of Electrocardiology |
| Volume: | 38 |
| Issue: | 4 |
| Start Page: | 364 |
| End Page: | 370 |
| Publisher DOI: | 10.1016/j.jelectrocard.2005.05.007 |
| PMID: | 16216614 |
| Abstract: | We have recently demonstrated that during pacing-induced sustained ventricular fibrillation (VF), perfusion of the heart with either ruthenium red (RR) or Ru 360, blockers of the mitochondrial Ca2+ uniporter, resulted in the reversible conversion of VF to ventricular tachycardia (VT). Here, we aimed at elucidating the electrophysiological mechanisms for the RR-induced conversion of VF to VT. The experiments were performed using Langendorff-perfused isolated rat hearts in which left ventricular pressure and left ventricular intracellular action potential were recorded. Perfusion with either RR or Ru 360 resulted in decreases in the action potential duration (APD), refractory period, and slope of APD restitution curves. These changes were antagonized by cotreatment with S(−)-Bay K8644. In addition, perfusion with verapamil produced the decreases in APD at 90% repolarization, refractory period and slope of APD restitution curves similar to the RR or Ru 360 perfusion. Such electrophysiological changes may be responsible for the reversible conversion of sustained VF to VT caused by perfusion with RR or Ru 360. |
| Relation: | http://www.sciencedirect.com/science/journal/00220736 |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/5930 |
| Appears in Collections: | 情報科学院・情報科学研究院 (Graduate School of Information Science and Technology / Faculty of Information Science and Technology) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 河原 剛一
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