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On the mechanisms for the conversion of ventricular fibrillation to tachycardia by perfusion with ruthenium red

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タイトル: On the mechanisms for the conversion of ventricular fibrillation to tachycardia by perfusion with ruthenium red
著者: Kimura, Hiroyuki 著作を一覧する
Kawahara, Koichi 著作を一覧する
Yamauchi, Yoshiko 著作を一覧する
Miyaki, Jyunichi 著作を一覧する
キーワード: Ventricular fibrillation
Ventricular tachycardia
Action potential duration
Mitochondria
Ruthenium red
Restitution curve
発行日: 2005年10月
出版者: Elsevier Inc.
誌名: Journal of Electrocardiology
巻: 38
号: 4
開始ページ: 364
終了ページ: 370
出版社 DOI: 10.1016/j.jelectrocard.2005.05.007
抄録: We have recently demonstrated that during pacing-induced sustained ventricular fibrillation (VF), perfusion of the heart with either ruthenium red (RR) or Ru 360, blockers of the mitochondrial Ca2+ uniporter, resulted in the reversible conversion of VF to ventricular tachycardia (VT). Here, we aimed at elucidating the electrophysiological mechanisms for the RR-induced conversion of VF to VT. The experiments were performed using Langendorff-perfused isolated rat hearts in which left ventricular pressure and left ventricular intracellular action potential were recorded. Perfusion with either RR or Ru 360 resulted in decreases in the action potential duration (APD), refractory period, and slope of APD restitution curves. These changes were antagonized by cotreatment with S(−)-Bay K8644. In addition, perfusion with verapamil produced the decreases in APD at 90% repolarization, refractory period and slope of APD restitution curves similar to the RR or Ru 360 perfusion. Such electrophysiological changes may be responsible for the reversible conversion of sustained VF to VT caused by perfusion with RR or Ru 360.
Relation (URI): http://www.sciencedirect.com/science/journal/00220736
資料タイプ: article (author version)
URI: http://hdl.handle.net/2115/5930
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 河原 剛一

 

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