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Spectral and correlation analyses of the verapamil-induced conversion of ventricular fibrillation to tachycardia in isolated rat hearts
| Title: | Spectral and correlation analyses of the verapamil-induced conversion of ventricular fibrillation to tachycardia in isolated rat hearts |
| Authors: | Kawahara, Koichi1 Browse this author →KAKEN DB | | Takase, Marei Browse this author | | Yamauchi, Yoshiko Browse this author →KAKEN DB | | Kimura, Hiroyuki Browse this author |
| Authors(alt): | 河原, 剛一1 |
| Keywords: | Ventricular fibrillation | | ventricular tachycardia | | VT/VF transition | | calcium channels | | verapamil |
| Issue Date: | Apr-2004 |
| Publisher: | Elsevier Inc. |
| Journal Title: | Journal of Electrocardiology |
| Volume: | 37 |
| Issue: | 2 |
| Start Page: | 89 |
| End Page: | 100 |
| Publisher DOI: | 10.1016/j.jelectrocard.2004.01.006 |
| Abstract: | Ventricular tachycardia (VT) is considered to be the most common precursor of ventricular fibrillation (VF). However, the mechanisms underlying the transition from VT to VF remain unclear. Here, we investigated whether and how perfusion of the heart with verapamil, a blocker of L-type calcium channels, changed the macro-dynamics of the heart between VT and VF. The experiments were performed with Langendorff perfused isolated rat hearts, in which left ventricular pressure and left ventricular cardiomyogram were measured. Sustained VT or VF was induced by burst pacing of the left ventricular muscles. During sustained VF, verapamil perfusion resulted in the conversion of VF to VT. A cross-correlation analysis between left ventricular cardiomyogram and left ventricular pressure revealed that the correlation coefficient was small during VF, but became larger during VT. This study showed that inactivation of L-type Ca2+ channels occurred during verapamil-induced conversion of pacing-induced sustained VF to VT, and characterized the changes in macro-dynamics of the heart associated with the transition. |
| Rights: | http://www.elsevier.com/wps/find/journaldescription.cws_home/623308/description |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/5932 |
| Appears in Collections: | 情報科学院・情報科学研究院 (Graduate School of Information Science and Technology / Faculty of Information Science and Technology) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 河原 剛一
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