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Three-dimensional imaging of biological cells with picosecond ultrasonics

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Title: Three-dimensional imaging of biological cells with picosecond ultrasonics
Authors: Danworaphong, Sorasak Browse this author
Tomoda, Motonobu Browse this author →KAKEN DB
Matsumoto, Yuki Browse this author
Matsuda, Osamu Browse this author →KAKEN DB
Ohashi, Toshiro Browse this author →KAKEN DB
Watanabe, Hiromu Browse this author
Nagayama, Masafumi Browse this author →KAKEN DB
Gohara, Kazutoshi Browse this author →KAKEN DB
Otsuka, Paul H. Browse this author
Wright, Oliver B. Browse this author →KAKEN DB
Issue Date: 21-Apr-2015
Publisher: American Institute of Physics
Journal Title: Applied physics letters
Volume: 106
Issue: 16
Start Page: 163701
Publisher DOI: 10.1063/1.4918275
Abstract: We use picosecond ultrasonics to image animal cells in vitro-a bovine aortic endothelial cell and a mouse adipose cell-fixed to Ti-coated sapphire. Tightly focused ultrashort laser pulses generate and detect GHz acoustic pulses, allowing three-dimensional imaging (x, y, and t) of the ultrasonic propagation in the cells with similar to 1 mu m lateral and similar to 150 nm depth resolutions. Time-frequency representations of the continuous-wavelet-transform amplitude of the optical reflectivity variations inside and outside the cells show GHz Brillouin oscillations, allowing the average sound velocities of the cells and their ultrasonic attenuation to be obtained as well as the average bulk moduli.
Rights: Copyright 2015 American Institute of Physics. This article may be downloaded for personal use only. Any other use requires prior permission of the author and the American Institute of Physics. The following article appeared in Appl. Phys. Lett. 106, 163701, 2015, and may be found at
Type: article
Appears in Collections:工学院・工学研究院 (Graduate School of Engineering / Faculty of Engineering) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: WRIGHT O. B.

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