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A strategy for synthesis of lipid nanoparticles using microfluidic devices with a mixer structure
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| Title: | A strategy for synthesis of lipid nanoparticles using microfluidic devices with a mixer structure |
| Authors: | Maeki, Masatoshi Browse this author | | Saito, Tatsuyoshi Browse this author | | Sato, Yusuke Browse this author | | Yasui, Takao Browse this author | | Kaji, Noritada Browse this author | | Ishida, Akihiko Browse this author | | Tani, Hirofumi Browse this author | | Baba, Yoshinobu Browse this author | | Harashima, Hideyoshi Browse this author | | Tokeshi, Manabu Browse this author →KAKEN DB |
| Issue Date: | 2015 |
| Publisher: | The Royal Society of Chemistry |
| Journal Title: | RSC advances |
| Volume: | 5 |
| Issue: | 57 |
| Start Page: | 46181 |
| End Page: | 46185 |
| Publisher DOI: | 10.1039/c5ra04690d |
| Abstract: | Formation behavior of lipid nanoparticles (LNPs) in microfluidic devices with a staggered herringbone micromixer (SHM) structure was investigated. The fundamental role for SHMs in LNP formation was demonstrated by determining such factors as the limiting SHM cycle numbers and the effect of flow rate. The SHM cycle numbers and the position of the first SHM were as significant as factors as the flow rate condition for producing the small-size LNPs. |
| Rights: | http://creativecommons.org/licenses/by-nc/3.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/59520 |
| Appears in Collections: | 工学院・工学研究院 (Graduate School of Engineering / Faculty of Engineering) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 真栄城 正寿
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