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A strategy for synthesis of lipid nanoparticles using microfluidic devices with a mixer structure

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Title: A strategy for synthesis of lipid nanoparticles using microfluidic devices with a mixer structure
Authors: Maeki, Masatoshi Browse this author
Saito, Tatsuyoshi Browse this author
Sato, Yusuke Browse this author
Yasui, Takao Browse this author
Kaji, Noritada Browse this author
Ishida, Akihiko Browse this author
Tani, Hirofumi Browse this author
Baba, Yoshinobu Browse this author
Harashima, Hideyoshi Browse this author
Tokeshi, Manabu Browse this author →KAKEN DB
Issue Date: 2015
Publisher: The Royal Society of Chemistry
Journal Title: RSC advances
Volume: 5
Issue: 57
Start Page: 46181
End Page: 46185
Publisher DOI: 10.1039/c5ra04690d
Abstract: Formation behavior of lipid nanoparticles (LNPs) in microfluidic devices with a staggered herringbone micromixer (SHM) structure was investigated. The fundamental role for SHMs in LNP formation was demonstrated by determining such factors as the limiting SHM cycle numbers and the effect of flow rate. The SHM cycle numbers and the position of the first SHM were as significant as factors as the flow rate condition for producing the small-size LNPs.
Rights: http://creativecommons.org/licenses/by-nc/3.0/
Type: article
URI: http://hdl.handle.net/2115/59520
Appears in Collections:工学院・工学研究院 (Graduate School of Engineering / Faculty of Engineering) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 真栄城 正寿

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