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Audition-Independent Vocal Crystallization Associated with Intrinsic Developmental Gene Expression Dynamics

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Title: Audition-Independent Vocal Crystallization Associated with Intrinsic Developmental Gene Expression Dynamics
Authors: Mori, Chihiro Browse this author
Wada, Kazuhiro Browse this author →KAKEN DB
Keywords: critical period
motor pattern generation
sensorimotor learning
species specificity
Issue Date: 21-Jan-2015
Publisher: Society for Neuroscience
Journal Title: Journal of Neuroscience
Volume: 35
Issue: 3
Start Page: 878
End Page: 889
Publisher DOI: 10.1523/JNEUROSCI.1804-14.2015
PMID: 25609608
Abstract: Complex learned behavior is influenced throughout development by both genetic and environmental factors. Birdsong, like human speech, is a complex vocal behavior acquired through sensorimotor learning and is based on coordinated auditory input and vocal output to mimic tutor song. Song is primarily learned during a specific developmental stage called the critical period. Although auditory input is crucial for acquiring complex vocal patterns, its exact role in neural circuit maturation for vocal learning and production is not well understood. Using audition-deprived songbirds, we examined whether auditory experience affects developmental gene expression in the major elements of neural circuits that mediate vocal learning and production. Compared with intact zebra finches, early-deafened zebra finches showed excessively delayed vocal development, but their songs eventually crystallized. In contrast to the different rates of song development between the intact and deafened birds, developmental gene expression in the motor circuit is conserved in an agedependent manner from the juvenile stage until the older adult stage, even in the deafened birds, which indicates the auditionindependent robustness of gene expression dynamics during development. Furthermore, even after adult deafening, which degrades crystallized song, the deteriorated songs ultimately restabilized at the same point when the early-deafened birds stabilized their songs. These results indicate a genetic program-associated inevitable termination of vocal plasticity that results in audition-independent vocal crystallization.
Type: article
Appears in Collections:理学院・理学研究院 (Graduate School of Science / Faculty of Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 和多 和宏

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