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Behavior of in vitro, in vivo and internal motion of micro/nano particles of titanium, titanium oxides and others

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Title: Behavior of in vitro, in vivo and internal motion of micro/nano particles of titanium, titanium oxides and others
Authors: Koyama, Chika Browse this author
Akasaka, Tsukasa Browse this author
Esaki, Mitsue Browse this author
Morita, Manabu Browse this author
Yonezawa, Tetsu Browse this author →KAKEN DB
Watari, Fumio Browse this author
Abe, Shigeaki Browse this author
Yokoyama, Atsuro Browse this author
Uo, Motohiro Browse this author
Matsuoka, Makoto Browse this author
Totsuka, Yasunori Browse this author
Keywords: Nanoparticle
Phagocytosis
Inflammation
Internal diffusion
Biocompatibility
Nanotoxicology
Cytokine
Size effect
Issue Date: 2008
Journal Title: Journal of the Ceramic Society of Japan
Volume: 116
Issue: 1349
Start Page: 1
End Page: 5
Publisher DOI: 10.2109/jcersj2.116.1
Abstract: To clarify the effect of micro/nanosizing of materials onto biological organism, the particle size dependence of reaction of cells and tissue as investigated by both biochemical cell functional test and animal implantation test. Especially for nanoparticles the behavior of invasion and internal diffusion inside body was visualized using an XSAM (X-ray Scanning Analytical Microscope). The increase of specific surface area is usually counted as nanosizing effect which causes the enhancement of chemical reactivity and therefore toxicity of materials such as carcinogenicity found in 500nm Ni particles for the long term implantation in the soft tissue of rat. Even biocompatible materials such as Ti and TiO_2 shows stimulus with the decrease of particle size. They cause phagocytosis to cells and inflammation to tissue when the size of particles is below 3μm. For the size below 50nm, they may invade into the internal body through the respiratory or digestive system and diffuse inside body. After compulsory exposure test of 30nm TiO_2 particles through the respiratory system, the Ti mapping by XSAM showed the internal diffusion inside the whole body. Nanoparticles injected from caudal vein diffused with time course to lung, liver and spleen. The uptake of 30nm TiO_2 particles through the digestive system and diffusion into these organs was also confirmed. These phenomena observed in biocompatible or bioinert materials are the nonspecific, physical particle and shape effects which occur independent of materials. Nanoparticles might be the objects whose existence has not been assumed by the living body defense system.
Type: article
URI: http://hdl.handle.net/2115/59708
Appears in Collections:工学院・工学研究院 (Graduate School of Engineering / Faculty of Engineering) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 米澤 徹

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