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Functional Significance of the Preconditioning-induced Down-regulation of Glutamate Transporter GLT-1 in Neuron/astrocyte Co-cultures

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Title: Functional Significance of the Preconditioning-induced Down-regulation of Glutamate Transporter GLT-1 in Neuron/astrocyte Co-cultures
Authors: Kosugi, Tatsuro Browse this author
Kawahara, Koichi2 Browse this author →KAKEN DB
Yamada, Takeshi Browse this author
Nakajima, Takayuki Browse this author
Tanaka, Motoki Browse this author
Authors(alt): 河原, 剛一2
Keywords: GLT-1
ischemic tolerance
neuron-derived factor
preconditioning
Issue Date: Sep-2005
Publisher: Springer Netherlands
Journal Title: Neurochemical Research
Volume: 30
Issue: 9
Start Page: 1109
End Page: 1116
Publisher DOI: 10.1007/s11064-005-8219-z
PMID: 16292503
Abstract: In the brain, prior sublethal ischemia (preconditioning, PC) is known to produce tolerance of neurons to subsequent lethal ischemia. This study aims at elucidating what alterations were induced in neurons and/or astrocytes by PC treatment. The rise in the extracellular concentration of glutamate during ischemia was markedly suppressed by the prior PC treatment. Immunocytochemical and Western blot analyses demonstrated that the expression of the astrocytic glutamate transporter GLT-1 was transiently down-regulated after the PC insult. The PC insult possibly suppressed the neuron-derived factors up-regulating GLT-1. Here we show that PC-induced down-regulation of GLT-1 is crucial for the increased neuronal resistance to subsequent severe ischemic insult.
Rights: The original publication is available at www.springerlink.com
Type: article (author version)
URI: http://hdl.handle.net/2115/5971
Appears in Collections:情報科学院・情報科学研究院 (Graduate School of Information Science and Technology / Faculty of Information Science and Technology) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 河原 剛一

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