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Micromorphological cellular responses of MC3T3-E1 and RAW264.7 after exposure to water-dispersible silver nanoparticles stabilized by metal-carbon σ-bonds

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タイトル: Micromorphological cellular responses of MC3T3-E1 and RAW264.7 after exposure to water-dispersible silver nanoparticles stabilized by metal-carbon σ-bonds
著者: HASHIMOTO, Masanori 著作を一覧する
TOSHIMA, Hirokazu 著作を一覧する
YONEZAWA, Tetsu 著作を一覧する
KAWAI, Koji 著作を一覧する
NARUSHIMA, Takashi 著作を一覧する
KAGA, Masayuki 著作を一覧する
ENDO, Kazuhiko 著作を一覧する
キーワード: Ag-NPs
Biocompatibility
Endocytosis
SEM
TEM
発行日: 2013年
出版者: Japanese Society for Dental Materials and Devices
誌名: Dental Materials Journal
巻: 32
号: 5
開始ページ: 725
終了ページ: 733
出版社 DOI: 10.4012/dmj.2012-203
抄録: With the continuous progress in nanomaterial development for biomedicine, the potential cytotoxicity of nanoparticles is drawing more attention and concern for clinical applications. The purpose of this study was to evaluate biological responses of new water-dispersible silver nanoparticles (Ag-NPs) stabilized by Ag-C σ-bonds in cultured marine macrophages (RAW264.7) and osteoblast-like cells (MC3T3-E1) using cell viability and morphological analyses. For RAW264.7, Ag-NPs seemed to induce cytotoxicity that was dependent on the Ag-NP concentration. However, no cytotoxic effects were observed in the MC3T3-E1 cell line. In microscopic analysis, Ag-NPs were taken up by MC3T3-E1 cells with only minor cell morphological changes, in contrast to RAW264.7 cells, in which particles aggregated in the cytoplasm and vesicles. The ability of endocytosis of macrophages may induce harmful effects due to expansion of cell vesicles compared to osteoblast-like cells with their lower uptake of Ag-NPs.
資料タイプ: article
URI: http://hdl.handle.net/2115/59713
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 米澤 徹

 

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