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Influence of Root Dentin Surface Conditioning with Bone Morphogenetic Protein-2 on Periodontal Wound Healing in Beagle Dogs

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Title: Influence of Root Dentin Surface Conditioning with Bone Morphogenetic Protein-2 on Periodontal Wound Healing in Beagle Dogs
Authors: MIYAJI, Hirofumi1 Browse this author →KAKEN DB
SUGAYA, Tsutomu2 Browse this author →KAKEN DB
IBE, Keisuke3 Browse this author
ISHIZUKA, Ryousuke4 Browse this author
TOKUNAGA, Keisuke5 Browse this author
KAWANAMI, Masamitsu6 Browse this author →KAKEN DB
Authors(alt): MIYAJI, Hirofumi1
SUGAYA, Tsutomu2
IBE, Keisuke3
ISHIZUKA, Ryousuke4
TOKUNAGA, Keisuke5
KAWANAMI, Masamitsu6
Keywords: bone morphogenetic protein-2
root dentin surface conditioning
periodontal wound healing
Issue Date: 30-Mar-2011
Publisher: Japanese Association of Regenerative Dentistry
Journal Title: Journal of Oral Tissue Engineering
Volume: 8
Issue: 3
Start Page: 173
End Page: 180
Publisher DOI: 10.11223/jarde.8.173
Abstract: Bone morphogenetic protein-2 (BMP-2) may play a major role in osteoinduction and osteoclast differentiation. The influence of BMP-2 conditioning in graded doses to root dentin surface on periodontal wound healing was examined.Twenty-four periodontal defects were surgically created on the buccal roots of four beagle dogs. The denuded root dentin surfaces were demineralized with 24% EDTA, 0.1 and 1.0 μg/μL BMP-2 solution (15 μL) was applied, and the groups were labeled as low-dose BMP (BL) and high-dose BMP (BH), respectively. In the control roots, phosphate-buffered saline was applied to the root surface. Specimens were histologically analyzed 16 weeks after surgery.Periodontal wound healing was stimulated by conditioning with BMP-2. Formation of alveolar bone and cementum-like tissue was observed; however, in BH group, ankylosis and root resorption were accelerated in the defect area, and there was little evidence of periodontal ligament formation between alveolar bone and root surface.
Rights: 日本再生歯科医学会(利用は著作権の範囲内に限られます)
Type: article
Appears in Collections:歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 宮治 裕史

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