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An instrument-free, screen-printed paper microfluidic device that enables bio and chemical sensing

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Title: An instrument-free, screen-printed paper microfluidic device that enables bio and chemical sensing
Authors: Mohammadi, Saeed Browse this author
Maeki, Masatoshi Browse this author
Mohamadi, Reza M. Browse this author
Ishida, Akihiko Browse this author
Tani, Hirofumi Browse this author
Tokeshi, Manabu Browse this author →KAKEN DB
Issue Date: 2015
Publisher: Royal Society of Chemistry
Journal Title: Analyst
Volume: 140
Issue: 19
Start Page: 6493
End Page: 6499
Publisher DOI: 10.1039/c5an00909j
PMID: 26207925
Abstract: This paper describes a simple and instrument-free screen-printing method to fabricate hydrophilic channels by patterning polydimethylsiloxane (PDMS) onto chromatography paper. Clearly recognizable border lines were formed between hydrophilic and hydrophobic areas. The minimum width of the printed channel to deliver an aqueous sample was 600 mu m, as obtained by this method. Fabricated microfluidic paper-based analytical devices (mu PADs) were tested for several colorimetric assays of pH, glucose, and protein in both buffer and artificial urine samples and results were obtained in less than 30 min. The limits of detection (LODs) for glucose and bovine serum albumin (BSA) were 5 mM and 8 mu M, respectively. Furthermore, the pH values of different solutions were visually recognised with the naked eye by using a sensitive ink. Ultimately, it is expected that this PDMS-screen-printing (PSP) methodology for mu PADs can be readily translated to other colorimetric detection and hydrophilic channels surrounded by a hydrophobic polymer can be formed to transport fluids toward target zones.
Type: article
Appears in Collections:工学院・工学研究院 (Graduate School of Engineering / Faculty of Engineering) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 渡慶次 学

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