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Improved spillover correction model to quantify myocardial blood flow by C-11-acetate PET : comparison with O-15-H2O PET

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タイトル: Improved spillover correction model to quantify myocardial blood flow by C-11-acetate PET : comparison with O-15-H2O PET
著者: Mori, Yuki 著作を一覧する
Manabe, Osamu 著作を一覧する
Naya, Masanao 著作を一覧する
Tomiyama, Yuuki 著作を一覧する
Yoshinaga, Keiichiro 著作を一覧する
Magota, Keiichi 著作を一覧する
Oyama-Manabe, Noriko 著作を一覧する
Hirata, Kenji 著作を一覧する
Tsutsui, Hiroyuki 著作を一覧する
Tamaki, Nagara 著作を一覧する
Katoh, Chietsugu 著作を一覧する
キーワード: C-11-acetate
Regional myocardial blood flow
Spillover correction
発行日: 2015年 1月
出版者: Springer
誌名: Annals of nuclear medicine
巻: 29
号: 1
開始ページ: 15
終了ページ: 20
出版社 DOI: 10.1007/s12149-014-0904-z
抄録: C-11-acetate has been applied for evaluation of myocardial oxidative metabolism and can simultaneously estimate myocardial blood flow (MBF). We developed a new method using two-parameter spillover correction to estimate regional MBF (rMBF) with C-11-acetate PET in reference to MBF derived from O-15-H2O PET. The usefulness of our new approach was evaluated compared to the conventional method using one-parameter spillover correction. Sixty-three subjects were examined with C-11-acetate and O-15-H2O dynamic PET at rest. Inflow rate of C-11-acetate (K1) was compared with MBF derived from O-15-H2O PET. For the derivation, the relationship between K1 and MBF from O-15-H2O was linked by the Renkin-Crone model in 20 subjects as a pilot group. One-parameter and two-parameter corrections were applied to suppress the spillover between left ventricular (LV) wall and LV cavity. Validation was set using the other 43 subjects' data. Finally, rMBFs were calculated using relational expression derived from the pilot-group data. The relationship between K1 and MBF derived from O-15-H2O PET was approximated as K1 = [1-0.764 x exp(-1.001/MBF)] MBF from the pilot data using the two-parameter method. In the validation set, the correlation coefficient between rMBF from C-11-acetate and O-15-H2O demonstrated a significantly higher relationship with the two-parameter spillover correction method than the one-parameter spillover correction method (r = 0.730, 0.592, respectively, p < 0.05). In C-11-acetate PET study, the new two-parameter spillover correction method dedicated more accurate and robust myocardial blood flow than the conventional one-parameter method.
Rights: The final publication is available at
資料タイプ: article (author version)
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 真鍋 治


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