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Improved spillover correction model to quantify myocardial blood flow by C-11-acetate PET : comparison with O-15-H2O PET

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Title: Improved spillover correction model to quantify myocardial blood flow by C-11-acetate PET : comparison with O-15-H2O PET
Authors: Mori, Yuki Browse this author
Manabe, Osamu Browse this author
Naya, Masanao Browse this author
Tomiyama, Yuuki Browse this author
Yoshinaga, Keiichiro Browse this author →KAKEN DB
Magota, Keiichi Browse this author →KAKEN DB
Oyama-Manabe, Noriko Browse this author →KAKEN DB
Hirata, Kenji Browse this author →KAKEN DB
Tsutsui, Hiroyuki Browse this author →KAKEN DB
Tamaki, Nagara Browse this author →KAKEN DB
Katoh, Chietsugu Browse this author
Keywords: C-11-acetate
Regional myocardial blood flow
Spillover correction
Issue Date: Jan-2015
Publisher: Springer
Journal Title: Annals of nuclear medicine
Volume: 29
Issue: 1
Start Page: 15
End Page: 20
Publisher DOI: 10.1007/s12149-014-0904-z
PMID: 25209232
Abstract: C-11-acetate has been applied for evaluation of myocardial oxidative metabolism and can simultaneously estimate myocardial blood flow (MBF). We developed a new method using two-parameter spillover correction to estimate regional MBF (rMBF) with C-11-acetate PET in reference to MBF derived from O-15-H2O PET. The usefulness of our new approach was evaluated compared to the conventional method using one-parameter spillover correction. Sixty-three subjects were examined with C-11-acetate and O-15-H2O dynamic PET at rest. Inflow rate of C-11-acetate (K1) was compared with MBF derived from O-15-H2O PET. For the derivation, the relationship between K1 and MBF from O-15-H2O was linked by the Renkin-Crone model in 20 subjects as a pilot group. One-parameter and two-parameter corrections were applied to suppress the spillover between left ventricular (LV) wall and LV cavity. Validation was set using the other 43 subjects' data. Finally, rMBFs were calculated using relational expression derived from the pilot-group data. The relationship between K1 and MBF derived from O-15-H2O PET was approximated as K1 = [1-0.764 x exp(-1.001/MBF)] MBF from the pilot data using the two-parameter method. In the validation set, the correlation coefficient between rMBF from C-11-acetate and O-15-H2O demonstrated a significantly higher relationship with the two-parameter spillover correction method than the one-parameter spillover correction method (r = 0.730, 0.592, respectively, p < 0.05). In C-11-acetate PET study, the new two-parameter spillover correction method dedicated more accurate and robust myocardial blood flow than the conventional one-parameter method.
Rights: The final publication is available at
Type: article (author version)
Appears in Collections:国際連携研究教育局 : GI-CoRE (Global Institution for Collaborative Research and Education : GI-CoRE) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 真鍋 治

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