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Transcription of 4'-thioDNA templates to natural RNA in vitro and in mammalian cells

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Title: Transcription of 4'-thioDNA templates to natural RNA in vitro and in mammalian cells
Authors: Maruyama, Hideto Browse this author
Furukawa, Kazuhiro Browse this author
Kamiya, Hiroyuki Browse this author →KAKEN DB
Minakawa, Noriaki Browse this author
Matsuda, Akira Browse this author →KAKEN DB
Issue Date: 7-May-2015
Publisher: Royal Society of Chemistry
Journal Title: Chemical communications
Volume: 51
Issue: 37
Start Page: 7887
End Page: 7890
Publisher DOI: 10.1039/c4cc08862j
PMID: 25854199
Abstract: Synthetic chemically modified nucleic acids, which are compatible with DNA/RNA polymerases, have great potential as a genetic material for synthetic biological studies. A comprehensive analysis of the transcription of 4'-thioDNA templates to natural RNA is herein reported. The modifications of DNA with 2'-deoxy-4'-thionucleosides, so-called 4'-thioDNA, were found to act as templates for transcription with RNA polymerases both in vitro and in mammalian cells.
Type: article (author version)
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 丸山 豪斗

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