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Title: 矯正学的歯の移動後の歯槽骨再形成に対する低出力超音波パルスの効果
Other Titles: Effect of low-intensity pulsed ultrasound on alveolar bone reformation following orthodontic tooth movement
Authors: 彦根, 敦 Browse this author
日下部, 豊寿 Browse this author →KAKEN DB
佐藤, 嘉晃 Browse this author →KAKEN DB
飯田, 順一郎 Browse this author →KAKEN DB
Keywords: Low-intensity pulsed ultrasound (LIPUS)
microfocus x-ray tomography
Issue Date: Mar-2016
Publisher: 北海道歯学会
Journal Title: 北海道歯学雑誌
Volume: 36
Issue: 2
Start Page: 63
End Page: 71
Abstract: 低出力超音波パルス(Low-Intensity Pulsed Ultrasound,以下LIPUS)は骨形成を促進することが知られており,骨折の治療などに臨床応用されている.本研究の目的は矯正学的歯の移動後の歯槽骨にLIPUSを照射することで,歯槽骨吸収部の骨再形成におよぼすLIPUSの影響を検討することである.  10週齢ウィスター系雄性ラットの上顎第一臼歯と第二臼歯間にゴムを挿入し,7日間歯を移動させた後,保定を目的にスーパーボンドにて固定した.7日間の保定期間中にLIPUS照射を行った.観察は歯の移動を行わない群(無処置群),歯の移動後の観察群(保定0日群),保定期間中にLIPUSを照射する群(LIPUS照射群)および照射しない群(対象群)に分けて行った.LIPUS照射条件は1.0MHz,240mW,出力モード20%とし,保定開始時より安楽死させる2日前まで1日1回15分,計6回頭頂部より照射を行った.歯の移動後,ならびに保定後7日後に安楽死させ,歯槽骨のμCTを撮影し,三次元解析ソフトにより上顎第一臼歯遠心口蓋根および上顎第二臼歯近心口蓋根間の歯槽骨の体積を計測した.また,組織学的観察を行った.  上顎第一臼歯遠心口蓋根および上顎第二臼歯近心口蓋根間の歯間中隔部歯槽骨の体積は無処置群に比して保定0日群で著しく減少し,7日間の保定期間後は増加していた.保定7日後のLIPUS照射群の歯槽骨体積は対照群に比して歯根中央部の範囲において有意に大きい値を示した.また,組織学的所見においてLIPUS照射群は対照群に比して歯間中隔部歯槽骨の骨形成が進んでおり,LIPUS照射によりすみやかな骨添加が生じることで時間的な差が生じていることが考えられた.これらの結果よりLIPUS照射は保定期間中の歯槽骨形成の促進に効果的であった.
Low-intensity pulsed ultrasound (LIPUS) promotes bone formation and is widely used for fracture healing in clinical medicine. The purpose of this study was to evaluate the effects of LIPUS on alveolar bone reformation following orthodontic tooth movement.  An elastic band was inserted between the upper first and second molars of 10-week-old rats. After 7 days, the band was removed and the molars were fixed by a retainer (super bond).  Four experimental groups were included : 1) rat with 7 days-tooth movement (Ret-0day group), 2) rat with subsequent observation (retention) for 7 days without LIPUS (control group), 3) rat with LIPUS( LIPUS group) ,and the untreated group.  A low-intensity pulsed ultrasound (1.0 MHz, 240 mW, 20% duty cycle, 15 min per day, 6days) was used. Animals were euthanized after tooth movement or after following retention period.  Bone volume of interalveolar septum between the first and second molars were determined using microfocus x-ray tomography and 3D-reconstruction technology. Histological evaluations were performed under a light microscope.  The bone volume of the Ret-0 day group was significantly lower when compared with the untreated group, and increased after retention. Bone volume of the LIPUS group at around the middle portion of the root was higher than the control group. Histological analysis pointed out bone formation in the interalveolar septum advanced in the LIPUS group rather than the control group. LIPUS accelerated bone formation thereby a difference occurred in time between the LIPUS group and the control group. The present study demonstrates that LIPUS promotes alveolar bone reformation in retention period.
Type: article
Appears in Collections:北海道歯学雑誌 = Hokkaido Journal of Dental Science > 第36巻 第2号

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