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Biological Response to Nanostructure of Carbon Nanotube/titanium Composite Surfaces

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Title: Biological Response to Nanostructure of Carbon Nanotube/titanium Composite Surfaces
Authors: Erika, Nishida Browse this author
Hirofumi, Miyaji Browse this author →KAKEN DB
Junko, Umeda Browse this author →KAKEN DB
Katsuyoshi, Kondoh Browse this author →KAKEN DB
Hiroko, Takita Browse this author →KAKEN DB
Izumi, Kanayama Browse this author
Saori, Tanaka Browse this author →KAKEN DB
Akihito, Kato Browse this author →KAKEN DB
Bunshi, Fugetsu Browse this author
Tsukasa, Akasaka Browse this author →KAKEN DB
Masamitsu, Kawanami Browse this author →KAKEN DB
Keywords: carbon nanotube
cell proliferation
Issue Date: 30-Jun-2015
Publisher: ナノバイオメディカル学会
Nano Biomedical Society
Journal Title: Nano Biomedicine
Volume: 7
Issue: 1
Start Page: 11
End Page: 20
Abstract: Titanium (Ti) is frequently used as a biomaterial in dental and orthopedic implants and in bone fixation devices. Effective modification of the Ti surface plays a crucial role in improving biocompatibility. Carbon nanotubes (CNTs) are among the most interesting nanomaterials due to their unique properties. In this study, we fabricated CNT-Ti composite surfaces by annealing Ti plates covered by different sized CNTs (Nanocyl NC 7000, 9.5 nm diameter and VGCF-H, 150 nm diameter). The properties of these surfaces were examined by scanning electron microscopy, X-ray diffraction, energy dispersive X-ray spectroscopy, raman spectroscopy, contact angle measurement and osteoblast-like cell seeding. In addition, samples were implanted into the subcutaneous tissue of rats. The three-dimensional nanostructures of CNTs and creation of titanium carbide were evident on the Ti surfaces, suggesting that the CNTs were well-anchored onto the Ti plates. CNT modification promoted desirable cell behavior, including cell spreading and proliferation, especially on the Nanocyl-modified surface. Inflammatory response was rarely observed on the Nanocyl surface, but macrophage-like giant cells were frequently observed on the VGCF-H surface. Therefore, the nanomorphology of narrow diameter CNTs provides a CNT-Ti composite surface with good biocompatibility.
Type: article
Appears in Collections:歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 宮治 裕史

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