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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Dental Medicine / Faculty of Dental Medicine >
Peer-reviewed Journal Articles, etc >
Biological Response to Nanostructure of Carbon Nanotube/titanium Composite Surfaces
| Title: | Biological Response to Nanostructure of Carbon Nanotube/titanium Composite Surfaces |
| Authors: | Erika, Nishida Browse this author | | Hirofumi, Miyaji Browse this author →KAKEN DB | | Junko, Umeda Browse this author →KAKEN DB | | Katsuyoshi, Kondoh Browse this author →KAKEN DB | | Hiroko, Takita Browse this author →KAKEN DB | | Izumi, Kanayama Browse this author | | Saori, Tanaka Browse this author →KAKEN DB | | Akihito, Kato Browse this author →KAKEN DB | | Bunshi, Fugetsu Browse this author | | Tsukasa, Akasaka Browse this author →KAKEN DB | | Masamitsu, Kawanami Browse this author →KAKEN DB |
| Keywords: | carbon nanotube | | titanium | | nanostructure | | cell proliferation | | biocompatibility |
| Issue Date: | 30-Jun-2015 |
| Publisher: | ナノバイオメディカル学会 | | Nano Biomedical Society |
| Journal Title: | Nano Biomedicine |
| Volume: | 7 |
| Issue: | 1 |
| Start Page: | 11 |
| End Page: | 20 |
| Abstract: | Titanium (Ti) is frequently used as a biomaterial in dental and orthopedic implants and in bone fixation devices. Effective modification of the Ti surface plays a crucial role in improving biocompatibility. Carbon nanotubes (CNTs) are among the most interesting nanomaterials due to their unique properties. In this study, we fabricated CNT-Ti composite surfaces by annealing Ti plates covered by different sized CNTs (Nanocyl NC 7000, 9.5 nm diameter and VGCF-H, 150 nm diameter). The properties of these surfaces were examined by scanning electron microscopy, X-ray diffraction, energy dispersive X-ray spectroscopy, raman spectroscopy, contact angle measurement and osteoblast-like cell seeding. In addition, samples were implanted into the subcutaneous tissue of rats. The three-dimensional nanostructures of CNTs and creation of titanium carbide were evident on the Ti surfaces, suggesting that the CNTs were well-anchored onto the Ti plates. CNT modification promoted desirable cell behavior, including cell spreading and proliferation, especially on the Nanocyl-modified surface. Inflammatory response was rarely observed on the Nanocyl surface, but macrophage-like giant cells were frequently observed on the VGCF-H surface. Therefore, the nanomorphology of narrow diameter CNTs provides a CNT-Ti composite surface with good biocompatibility. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/61559 |
| Appears in Collections: | 歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 宮治 裕史
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