We propose a new type of axion inflation with complex structure moduli in the framework of type IIB superstring theory compactified on the Calabi-Yau manifold. The inflaton is identified as the axion for the complex structure moduli whose potential is originating from instantonic corrections appearing through the period vector of the mirror Calabi-Yau manifold. The axionic shift symmetry is broken down to the discrete one by the inclusion of the instantonic correction and certain three-form fluxes. Our proposed inflation scenario is compatible with Kahler moduli stabilization. We also study a typical reheating temperature in the case of complex structure moduli inflation.