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Divergent bufavirus harboured in megabats represents a new lineage of parvoviruses.

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Title: Divergent bufavirus harboured in megabats represents a new lineage of parvoviruses.
Authors: Sasaki, Michihito Browse this author →KAKEN DB
Gonzalez, Gabriel Browse this author
Wada, Yuji Browse this author
Setiyono, Agus Browse this author
Handharyani, Ekowati Browse this author
Rahmadani, Ibenu Browse this author
Taha, Siswatiana Browse this author
Adiani, Sri Browse this author
Latief, Munira Browse this author
Kholilullah, Zainal Abidin Browse this author
Subangkit, Mawar Browse this author
Kobayashi, Shintaro Browse this author →KAKEN DB
Nakamura, Ichiro Browse this author →KAKEN DB
Kimura, Takashi Browse this author →KAKEN DB
Orba, Yasuko Browse this author →KAKEN DB
Ito, Kimihito Browse this author →KAKEN DB
Sawa, Hirofumi Browse this author →KAKEN DB
Issue Date: 26-Apr-2016
Publisher: Nature Publishing Group
Journal Title: Scientific reports
Volume: 6
Start Page: 24257
Publisher DOI: 10.1038/srep24257
PMID: 27113297
Abstract: Bufavirus is a recently recognized member of the genus Protoparvovirus in the subfamily Parvovirinae. It has been reported that human bufavirus was detected predominantly in patients with diarrhoea in several countries. However, little is known about bufavirus or its close relatives in nonhuman mammals. In this study, we performed nested-PCR screening and identified bufavirus from 12 megabats of Pteropus spp. in Indonesia. Furthermore, we determined nearly the full genome sequence of a novel megabat-borne bufavirus, tentatively named megabat bufavirus 1. Phylogenetic analyses showed that megabat bufavirus 1 clustered with known protoparvoviruses, including human bufavirus but represented a distinct lineage of bufavirus. Our analyses also inferred phylogenetic relationships among animal-borne bufaviruses recently reported by other studies. Recombination analyses suggested that the most common recent ancestor of megabat bufavirus 1 might have arisen from multiple genetic recombination events. These results characterized megabat bufavirus 1 as the first protoparvovirus discovered from megabats and indicates the high genetic divergence of bufavirus.
Type: article
Appears in Collections:人獣共通感染症リサーチセンター (Research Center for Zoonosis Control) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 佐々木 道仁

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