| Title: | Divergent bufavirus harboured in megabats represents a new lineage of parvoviruses. |
| Authors: | Sasaki, Michihito Browse this author →KAKEN DB |
| Gonzalez, Gabriel Browse this author |
| Wada, Yuji Browse this author |
| Setiyono, Agus Browse this author |
| Handharyani, Ekowati Browse this author |
| Rahmadani, Ibenu Browse this author |
| Taha, Siswatiana Browse this author |
| Adiani, Sri Browse this author |
| Latief, Munira Browse this author |
| Kholilullah, Zainal Abidin Browse this author |
| Subangkit, Mawar Browse this author |
| Kobayashi, Shintaro Browse this author →KAKEN DB |
| Nakamura, Ichiro Browse this author →KAKEN DB |
| Kimura, Takashi Browse this author →KAKEN DB |
| Orba, Yasuko Browse this author →KAKEN DB |
| Ito, Kimihito Browse this author →KAKEN DB |
| Sawa, Hirofumi Browse this author →KAKEN DB |
| Issue Date: | 26-Apr-2016 |
| Publisher: | Nature Publishing Group |
| Journal Title: | Scientific reports |
| Volume: | 6 |
| Start Page: | 24257 |
| Publisher DOI: | 10.1038/srep24257 |
| PMID: | 27113297 |
| Abstract: | Bufavirus is a recently recognized member of the genus Protoparvovirus in the subfamily Parvovirinae. It has been reported that human bufavirus was detected predominantly in patients with diarrhoea in several countries. However, little is known about bufavirus or its close relatives in nonhuman mammals. In this study, we performed nested-PCR screening and identified bufavirus from 12 megabats of Pteropus spp. in Indonesia. Furthermore, we determined nearly the full genome sequence of a novel megabat-borne bufavirus, tentatively named megabat bufavirus 1. Phylogenetic analyses showed that megabat bufavirus 1 clustered with known protoparvoviruses, including human bufavirus but represented a distinct lineage of bufavirus. Our analyses also inferred phylogenetic relationships among animal-borne bufaviruses recently reported by other studies. Recombination analyses suggested that the most common recent ancestor of megabat bufavirus 1 might have arisen from multiple genetic recombination events. These results characterized megabat bufavirus 1 as the first protoparvovirus discovered from megabats and indicates the high genetic divergence of bufavirus. |
| Rights: | http://creativecommons.org/licenses/by/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/61965 |
| Appears in Collections: | 人獣共通感染症国際共同研究所 (International Institute for Zoonosis Control) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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