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PML suppresses IL-6-induced STAT3 activation by interfering with STAT3 and HDAC3 interaction
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Title: | PML suppresses IL-6-induced STAT3 activation by interfering with STAT3 and HDAC3 interaction |
Authors: | Kato, Masaya Browse this author | Muromoto, Ryuta Browse this author →KAKEN DB | Togi, Sumihito Browse this author | Iwakami, Masashi Browse this author | Kitai, Yuichi Browse this author →KAKEN DB | Kon, Shigeyuki Browse this author →KAKEN DB | Oritani, Kenji Browse this author →KAKEN DB | Matsuda, Tadashi Browse this author →KAKEN DB |
Keywords: | IL-6 | STAT3 | PML | HDAC3 | Hepatoma | Transcriptional regulation |
Issue Date: | 29-May-2015 |
Publisher: | Elsevier |
Journal Title: | Biochemical and biophysical research communications |
Volume: | 461 |
Issue: | 2 |
Start Page: | 366 |
End Page: | 371 |
Publisher DOI: | 10.1016/j.bbrc.2015.04.040 |
PMID: | 25892518 |
Abstract: | The promyelocytic leukemia protein PML acts as a tumor suppressor by forming transcription-regulatory complexes with a variety of repressor proteins. In the present study, we found that endogenous PML suppresses interleukin (IL)-6-induced gene expression as well as phosphorylation and transcriptional activation of STAT3 in hepatoma cells. We also found that PML-mediated suppression of IL-6-induced STAT3 activation by disrupting interactions between STAT3 and HDAC3. These results indicate that PML modulates IL-6-induced STAT3 activation and hepatoma cell growth by interacting with HDAC3. (C) 2015 Elsevier Inc. All rights reserved. |
Rights: | © 2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
Type: | article (author version) |
URI: | http://hdl.handle.net/2115/61991 |
Appears in Collections: | 薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 松田 正
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