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PML suppresses IL-6-induced STAT3 activation by interfering with STAT3 and HDAC3 interaction

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Title: PML suppresses IL-6-induced STAT3 activation by interfering with STAT3 and HDAC3 interaction
Authors: Kato, Masaya Browse this author
Muromoto, Ryuta Browse this author →KAKEN DB
Togi, Sumihito Browse this author
Iwakami, Masashi Browse this author
Kitai, Yuichi Browse this author →KAKEN DB
Kon, Shigeyuki Browse this author →KAKEN DB
Oritani, Kenji Browse this author →KAKEN DB
Matsuda, Tadashi Browse this author →KAKEN DB
Keywords: IL-6
Transcriptional regulation
Issue Date: 29-May-2015
Publisher: Elsevier
Journal Title: Biochemical and biophysical research communications
Volume: 461
Issue: 2
Start Page: 366
End Page: 371
Publisher DOI: 10.1016/j.bbrc.2015.04.040
PMID: 25892518
Abstract: The promyelocytic leukemia protein PML acts as a tumor suppressor by forming transcription-regulatory complexes with a variety of repressor proteins. In the present study, we found that endogenous PML suppresses interleukin (IL)-6-induced gene expression as well as phosphorylation and transcriptional activation of STAT3 in hepatoma cells. We also found that PML-mediated suppression of IL-6-induced STAT3 activation by disrupting interactions between STAT3 and HDAC3. These results indicate that PML modulates IL-6-induced STAT3 activation and hepatoma cell growth by interacting with HDAC3. (C) 2015 Elsevier Inc. All rights reserved.
Rights: © 2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
Type: article (author version)
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 松田 正

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