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Enantioselective Borylative Dearomatization of Indoles through Copper(I) Catalysis

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Title: Enantioselective Borylative Dearomatization of Indoles through Copper(I) Catalysis
Authors: Kubota, Koji Browse this author
Hayama, Keiichi Browse this author
Iwamoto, Hiroaki Browse this author
Ito, Hajime Browse this author →KAKEN DB
Keywords: borylation
enantioselective synthesis
Issue Date: 20-Jun-2015
Publisher: Wiley-Blackwell
Journal Title: Angewandte chemie international edition
Volume: 54
Issue: 30
Start Page: 8809
End Page: 8813
Publisher DOI: 10.1002/anie.201502964
PMID: 26095335
Abstract: The enantioselective borylative dearomatization of a heteroaromatic compound has been achieved using a copper(I) catalyst and a diboron reagent. This reaction involves the regio- and enantioselective addition of active borylcopper(I) species to indole-2-carboxylates, followed by the diastereoselective protonation of the resulting copper(I) enolate to give the corresponding chiral indolines, which bear consecutive stereogenic centers.
Rights: This is the accepted version of the following article: Angewandte Chemie International Edition July 20, 2015, 54(30), pp.8809-8813, which has been published in final form at
Type: article (author version)
Appears in Collections:工学院・工学研究院 (Graduate School of Engineering / Faculty of Engineering) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 伊藤 肇

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