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Enantioselective Borylative Dearomatization of Indoles through Copper(I) Catalysis
| Title: | Enantioselective Borylative Dearomatization of Indoles through Copper(I) Catalysis |
| Authors: | Kubota, Koji Browse this author | | Hayama, Keiichi Browse this author | | Iwamoto, Hiroaki Browse this author | | Ito, Hajime Browse this author →KAKEN DB |
| Keywords: | borylation | | copper | | dearomatization | | enantioselective synthesis | | indoles |
| Issue Date: | 20-Jun-2015 |
| Publisher: | Wiley-Blackwell |
| Journal Title: | Angewandte chemie international edition |
| Volume: | 54 |
| Issue: | 30 |
| Start Page: | 8809 |
| End Page: | 8813 |
| Publisher DOI: | 10.1002/anie.201502964 |
| PMID: | 26095335 |
| Abstract: | The enantioselective borylative dearomatization of a heteroaromatic compound has been achieved using a copper(I) catalyst and a diboron reagent. This reaction involves the regio- and enantioselective addition of active borylcopper(I) species to indole-2-carboxylates, followed by the diastereoselective protonation of the resulting copper(I) enolate to give the corresponding chiral indolines, which bear consecutive stereogenic centers. |
| Rights: | This is the accepted version of the following article: Angewandte Chemie International Edition July 20, 2015, 54(30), pp.8809-8813, which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1002/anie.201502964/abstract. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/62248 |
| Appears in Collections: | 工学院・工学研究院 (Graduate School of Engineering / Faculty of Engineering) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 伊藤 肇
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