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CCR7 is involved in BCR-ABL/STAP-2-mediated cell growth in hematopoietic Ba/F3 cells
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Title: | CCR7 is involved in BCR-ABL/STAP-2-mediated cell growth in hematopoietic Ba/F3 cells |
Authors: | Kubo, Kaori Browse this author | Iwakami, Masashi Browse this author | Muromoto, Ryuta Browse this author | Inagaki, Takuya Browse this author | Kitai, Yuichi Browse this author →KAKEN DB | Kon, Shigeyuki Browse this author →KAKEN DB | Sekine, Yuichi Browse this author →KAKEN DB | Oritani, Kenji Browse this author →KAKEN DB | Matsuda, Tadashi Browse this author →KAKEN DB |
Keywords: | CML | BCR-ABL | STAP-2 | CCR7 | MAPK/ERK |
Issue Date: | 7-Aug-2015 |
Publisher: | Elsevier |
Journal Title: | Biochemical and biophysical research communications |
Volume: | 463 |
Issue: | 4 |
Start Page: | 825 |
End Page: | 831 |
Publisher DOI: | 10.1016/j.bbrc.2015.06.020 |
PMID: | 26102025 |
Abstract: | Chronic myeloid leukemia is a clonal disease characterized by the presence of the Philadelphia chromosome and its oncogenic product, BCR-ABL, which activates multiple pathways involved in cell survival, growth promotion, and disease progression. We previously reported that in murine hematopoietic Ba/F3 cells, signal transducing adaptor protein-2 (STAP-2) binds to BCR-ABL and up-regulates BCR-ABL phosphorylation, leading to enhanced activation of its downstream signaling molecules. The binding of STAP2 to BCR-ABL also influenced the expression levels of chemokine receptors, such as CXCR4 and CCR7. For the induction of CCR7 expression, signals mediated by the MAPK/ERK pathway were critical in Ba/F3 cells expressing BCR-ABL and STAP-2. In addition, STAP-2 cooperated with BCR-ABL to induce the production of CCR7 ligands, CCL19 and CCL21. Our results demonstrate a contribution of CCR7 to STAP-2-dependent enhancement of BCR-ABL-mediated cell growth in Ba/F3 cells. (C) 2015 Elsevier Inc. All rights reserved. |
Rights: | © 2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
Type: | article (author version) |
URI: | http://hdl.handle.net/2115/62630 |
Appears in Collections: | 薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 松田 正
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