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The efficacy of superselective intra-arterial infusion with concomitant radiotherapy for adenoid cystic carcinoma of the head and neck

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タイトル: The efficacy of superselective intra-arterial infusion with concomitant radiotherapy for adenoid cystic carcinoma of the head and neck
著者: Homma, Akihiro 著作を一覧する
Sakashita, Tomohiro 著作を一覧する
Hatakeyama, Hiromitsu 著作を一覧する
Kano, Satoshi 著作を一覧する
Mizumachi, Takatsugu 著作を一覧する
Nakamaru, Yuji 著作を一覧する
Yoshida, Daisuke 著作を一覧する
Onimaru, Rikiya 著作を一覧する
Tsuchiya, Kazuhiko 著作を一覧する
Yasuda, Koichi 著作を一覧する
Shirato, Hiroki 著作を一覧する
Fukuda, Satoshi 著作を一覧する
キーワード: Intra-arterial
cisplatin
adenoid cystic carcinoma
head and neck
chemotherapy
radiotherapy
発行日: 2015年
出版者: Taylor & Francis
誌名: Acta oto-laryngologica
巻: 135
号: 9
開始ページ: 950
終了ページ: 954
出版社 DOI: 10.3109/00016489.2015.1040171
抄録: Conclusions: Superselective intra-arterial cisplatin infusion with concomitant radiotherapy (RADPLAT) is considered to be one of the treatments of choice for patients with adenoid cystic carcinoma (ACC) who prefer not to undergo radical surgery. Objective: To evaluate the efficacy of RADPLAT for patients with ACC of the head and neck. Patients and methods: Between 2001-2010, nine patients with untreated ACC were given superselective intra-arterial infusion of cisplatin (100-120 mg/m(2)/ week) with simultaneous intravenous infusion of thiosulfate to neutralize cisplatin toxicity and radiotherapy (65-70 Gy). Results: Five patients had tumors arising in the base of the tongue, two in the maxillary sinus, and the remaining two in the nasopharynx. The median follow-up period was 9 years 7 months (9; 7) (range = 4; 6-12; 5), and the 5-year local control (LC), overall survival (OS), and disease-free survival rates were 88.9%, 88.9%, and 55.6%, respectively. The 10-year OS rate was 57.1%, but all patients who remained alive for over 10 years are still alive with disease. Primary tumor recurrence was observed in five of the nine patients, with the median time to recurrence being 6 years (range = 4-9 years). Five of the nine patients had distant metastasis, and of these three patients also had primary recurrence.
Rights: This is an Accepted Manuscript of an article published by Taylor & Francis in Acta Oto-Laryngologica in 2015, available online: http://www.tandfonline.com/10.3109/00016489.2015.1040171.
資料タイプ: article (author version)
URI: http://hdl.handle.net/2115/62737
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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