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The efficacy of superselective intra-arterial infusion with concomitant radiotherapy for adenoid cystic carcinoma of the head and neck

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/62737

Title: The efficacy of superselective intra-arterial infusion with concomitant radiotherapy for adenoid cystic carcinoma of the head and neck
Authors: Homma, Akihiro Browse this author →KAKEN DB
Sakashita, Tomohiro Browse this author →KAKEN DB
Hatakeyama, Hiromitsu Browse this author →KAKEN DB
Kano, Satoshi Browse this author →KAKEN DB
Mizumachi, Takatsugu Browse this author →KAKEN DB
Nakamaru, Yuji Browse this author →KAKEN DB
Yoshida, Daisuke Browse this author
Onimaru, Rikiya Browse this author →KAKEN DB
Tsuchiya, Kazuhiko Browse this author →KAKEN DB
Yasuda, Koichi Browse this author →KAKEN DB
Shirato, Hiroki Browse this author →KAKEN DB
Fukuda, Satoshi Browse this author →KAKEN DB
Keywords: Intra-arterial
cisplatin
adenoid cystic carcinoma
head and neck
chemotherapy
radiotherapy
Issue Date: 2015
Publisher: Taylor & Francis
Journal Title: Acta oto-laryngologica
Volume: 135
Issue: 9
Start Page: 950
End Page: 954
Publisher DOI: 10.3109/00016489.2015.1040171
Abstract: Conclusions: Superselective intra-arterial cisplatin infusion with concomitant radiotherapy (RADPLAT) is considered to be one of the treatments of choice for patients with adenoid cystic carcinoma (ACC) who prefer not to undergo radical surgery. Objective: To evaluate the efficacy of RADPLAT for patients with ACC of the head and neck. Patients and methods: Between 2001-2010, nine patients with untreated ACC were given superselective intra-arterial infusion of cisplatin (100-120 mg/m(2)/ week) with simultaneous intravenous infusion of thiosulfate to neutralize cisplatin toxicity and radiotherapy (65-70 Gy). Results: Five patients had tumors arising in the base of the tongue, two in the maxillary sinus, and the remaining two in the nasopharynx. The median follow-up period was 9 years 7 months (9; 7) (range = 4; 6-12; 5), and the 5-year local control (LC), overall survival (OS), and disease-free survival rates were 88.9%, 88.9%, and 55.6%, respectively. The 10-year OS rate was 57.1%, but all patients who remained alive for over 10 years are still alive with disease. Primary tumor recurrence was observed in five of the nine patients, with the median time to recurrence being 6 years (range = 4-9 years). Five of the nine patients had distant metastasis, and of these three patients also had primary recurrence.
Rights: This is an Accepted Manuscript of an article published by Taylor & Francis in Acta Oto-Laryngologica in 2015, available online: http://www.tandfonline.com/10.3109/00016489.2015.1040171.
Type: article (author version)
URI: http://hdl.handle.net/2115/62737
Appears in Collections:国際連携研究教育局 : GI-CoRE (Global Institution for Collaborative Research and Education : GI-CoRE) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 本間 明宏

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