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An analysis of membrane fusion between mitochondrial double membranes and MITO-Porter, mitochondrial fusogenic vesicles
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| Title: | An analysis of membrane fusion between mitochondrial double membranes and MITO-Porter, mitochondrial fusogenic vesicles |
| Authors: | Yamada, Yuma Browse this author →KAKEN DB | | Fukuda, Yutaka Browse this author | | Harashima, Hideyoshi Browse this author →KAKEN DB |
| Keywords: | Mitochondria | | Mitochondrial drug delivery | | Nucleic acid delivery | | Mitochondrial matrix | | MITO-Porter | | Membrane fusion |
| Issue Date: | Sep-2015 |
| Publisher: | Elsevier |
| Journal Title: | Mitochondrion |
| Volume: | 24 |
| Start Page: | 50 |
| End Page: | 55 |
| Publisher DOI: | 10.1016/j.mito.2015.07.003 |
| PMID: | 26188112 |
| Abstract: | To achieve mitochondrial gene therapy, therapeutic molecules need to be transported through the outer and inner membranes of mitochondria into the innermost space (mitochondrial matrix), which contains the mtDNA pool. We previously reported on the construction of a MITO-Porter with a high fusogenic activity for the mitochondrial outer membrane for delivering molecules to the mitochondria of human cells. Here, we report on an investigation of a fusogenic lipid composition for the inner membrane, and an analysis of the fusogenic compositions for the outer and inner membranes. A significant relationship was found between fusion activity and the mitochondrial delivery of nucleic acids. (C) 2015 Elsevier B.V. and Mitochondria Research Society. All rights reserved. |
| Rights: | © 2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/62755 |
| Appears in Collections: | 薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 山田 勇磨
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