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An analysis of membrane fusion between mitochondrial double membranes and MITO-Porter, mitochondrial fusogenic vesicles

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Title: An analysis of membrane fusion between mitochondrial double membranes and MITO-Porter, mitochondrial fusogenic vesicles
Authors: Yamada, Yuma Browse this author →KAKEN DB
Fukuda, Yutaka Browse this author
Harashima, Hideyoshi Browse this author →KAKEN DB
Keywords: Mitochondria
Mitochondrial drug delivery
Nucleic acid delivery
Mitochondrial matrix
MITO-Porter
Membrane fusion
Issue Date: Sep-2015
Publisher: Elsevier
Journal Title: Mitochondrion
Volume: 24
Start Page: 50
End Page: 55
Publisher DOI: 10.1016/j.mito.2015.07.003
PMID: 26188112
Abstract: To achieve mitochondrial gene therapy, therapeutic molecules need to be transported through the outer and inner membranes of mitochondria into the innermost space (mitochondrial matrix), which contains the mtDNA pool. We previously reported on the construction of a MITO-Porter with a high fusogenic activity for the mitochondrial outer membrane for delivering molecules to the mitochondria of human cells. Here, we report on an investigation of a fusogenic lipid composition for the inner membrane, and an analysis of the fusogenic compositions for the outer and inner membranes. A significant relationship was found between fusion activity and the mitochondrial delivery of nucleic acids. (C) 2015 Elsevier B.V. and Mitochondria Research Society. All rights reserved.
Rights: © 2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
http://creativecommons.org/licenses/by-nc-nd/4.0/
Type: article (author version)
URI: http://hdl.handle.net/2115/62755
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 山田 勇磨

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