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Identification and characterization of a dipeptidyl peptidase IV inhibitor from aronia juice

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タイトル: Identification and characterization of a dipeptidyl peptidase IV inhibitor from aronia juice
著者: Kozuka, Miyuki 著作を一覧する
Yamane, Takuya 著作を一覧する
Nakano, Yoshihisa 著作を一覧する
Nakagaki, Takenori 著作を一覧する
Ohkubo, Iwao 著作を一覧する
Ariga, Hiroyoshi 著作を一覧する
キーワード: Aronia juice
DPP IV inhibitor
Cyanidin 3, 5-diglucoside
Antidiabetic effect
発行日: 2015年 9月25日
出版者: Elsevier
誌名: Biochemical and biophysical research communications
巻: 465
号: 3
開始ページ: 433
終了ページ: 436
出版社 DOI: 10.1016/j.bbrc.2015.08.031
抄録: Aronia berries have many potential effects on health, including an antioxidant effect, effect for antimutagenesis, hepatoprotection and cardioprotection, an antidiabetic effect and inhibition of cancer cell proliferation. Previous human studies have shown that aronia juice may be useful for treatment of obesity disorders. In this study, we found that aronia juice has an inhibitory effect against dipeptidyl peptidase IV (DPP IV) (EC 3.4.14.5). DPP IV is a peptidase that cleaves the N-terminal region of incretins such as glucagon-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1). Inactivation of incretins by DPP IV induces reduction of insulin secretion. Furthermore, we identified that cyanidin 3, 5-diglucoside as the DPP IV inhibitor in aronia juice. DPP IV was inhibited more strongly by cyanidin 3, 5-diglucoside than by cyanidin and cyanidin 3-glucoside. The results suggest that DPP IV is inhibited by cyanidin 3, 5-diglucoside present in aronia juice. The antidiabetic effect of aronia juice may be mediated through DPP IV inhibition by cyanidin 3, 5-diglucoside.
Rights: © 2015, Elsevier. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
資料タイプ: article (author version)
URI: http://hdl.handle.net/2115/62868
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 山根 拓也

 

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