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Identification and characterization of a dipeptidyl peptidase IV inhibitor from aronia juice

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Title: Identification and characterization of a dipeptidyl peptidase IV inhibitor from aronia juice
Authors: Kozuka, Miyuki Browse this author
Yamane, Takuya Browse this author
Nakano, Yoshihisa Browse this author →KAKEN DB
Nakagaki, Takenori Browse this author
Ohkubo, Iwao Browse this author →KAKEN DB
Ariga, Hiroyoshi Browse this author →KAKEN DB
Keywords: Aronia juice
DPP IV inhibitor
Cyanidin 3, 5-diglucoside
Antidiabetic effect
Issue Date: 25-Sep-2015
Publisher: Elsevier
Journal Title: Biochemical and biophysical research communications
Volume: 465
Issue: 3
Start Page: 433
End Page: 436
Publisher DOI: 10.1016/j.bbrc.2015.08.031
PMID: 26296465
Abstract: Aronia berries have many potential effects on health, including an antioxidant effect, effect for antimutagenesis, hepatoprotection and cardioprotection, an antidiabetic effect and inhibition of cancer cell proliferation. Previous human studies have shown that aronia juice may be useful for treatment of obesity disorders. In this study, we found that aronia juice has an inhibitory effect against dipeptidyl peptidase IV (DPP IV) (EC 3.4.14.5). DPP IV is a peptidase that cleaves the N-terminal region of incretins such as glucagon-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1). Inactivation of incretins by DPP IV induces reduction of insulin secretion. Furthermore, we identified that cyanidin 3, 5-diglucoside as the DPP IV inhibitor in aronia juice. DPP IV was inhibited more strongly by cyanidin 3, 5-diglucoside than by cyanidin and cyanidin 3-glucoside. The results suggest that DPP IV is inhibited by cyanidin 3, 5-diglucoside present in aronia juice. The antidiabetic effect of aronia juice may be mediated through DPP IV inhibition by cyanidin 3, 5-diglucoside.
Rights: © 2015, Elsevier. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
http://creativecommons.org/licenses/by-nc-nd/4.0/
Type: article (author version)
URI: http://hdl.handle.net/2115/62868
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 山根 拓也

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