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Patterning nanofibrils through the templated growth of multiple modified amyloid peptides

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Title: Patterning nanofibrils through the templated growth of multiple modified amyloid peptides
Authors: Sakai, Hiroki Browse this author
Watanabe, Ken Browse this author
Kudoh, Fuki Browse this author
Kamada, Rui Browse this author
Chuman, Yoshiro Browse this author
Sakaguchi, Kazuyasu Browse this author
Issue Date: 26-Aug-2016
Publisher: Nature Publishing Group
Journal Title: Scientific reports
Volume: 6
Start Page: 31993
Publisher DOI: 10.1038/srep31993
Abstract: There has been considerable interest in the patterning of functionalized nanowires because of the potential applications of these materials to the construction of nanodevices. A variety of biomolecular building blocks containing amyloid peptides have been used to functionalize nanowires. However, the patterning of self-assembled nanowires can be challenging because of the difficulties associated with controlling the self-assembly of these functionalized building blocks. Herein, we present a versatile approach for the patterning of nanowires based on the combination of templated fibril growth with a versatile functionalization method using our structure-controllable amyloid peptides (SCAPs). Using this approach, we have succeeded in the formation of multi-type nanowires with tandem domain structures in high yields. Given that the mixing-SCAP method can lead to the formation of tandem fibrils, it is noteworthy that our method allowed us to control the initiation of fibril formation from the gold nanoparticles, which were attached to a short fibril as initiation points. This approach could be used to prepare a wide variety of fibril patterns, and therefore holds great potential for the development of novel self-assembled nanodevices.
Type: article
Appears in Collections:理学院・理学研究院 (Graduate School of Science / Faculty of Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 坂口 和靖

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