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PPM1D controls nucleolar formation by up-regulating phosphorylation of nucleophosmin

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/63135

Title: PPM1D controls nucleolar formation by up-regulating phosphorylation of nucleophosmin
Authors: Kozakai, Yuuki Browse this author
Kamada, Rui Browse this author
Furuta, Junya Browse this author
Kiyota, Yuhei Browse this author
Chuman, Yoshiro Browse this author
Sakaguchi, Kazuyasu Browse this author
Issue Date: 13-Sep-2016
Publisher: Nature Publishing Group
Journal Title: Scientific Reports
Volume: 6
Start Page: 33272
Publisher DOI: 10.1038/srep33272
Abstract: An increase of nucleolar number and size has made nucleoli essential markers for cytology and tumour development. However, the underlying basis for their structural integrity and abundance remains unclear. Protein phosphatase PPM1D was found to be up-regulated in different carcinomas including breast cancers. Here, we demonstrate for the first time that PPM1D regulates nucleolar formation via inducing an increased phosphorylation of the nucleolar protein NPM. We show that PPM1D overexpression induces an increase in the nucleolar number regardless of p53 status. We also demonstrated that specific sequential phosphorylation of NPM is important for nucleolar formation and that PPM1D is a novel upstream regulator of this phosphorylation pathway. These results enhance our understanding of the molecular mechanisms that govern nucleoli formation by demonstrating that PPM1D regulates nucleolar formation by regulating NPM phosphorylation status through a novel signalling pathway, PPM1D-CDC25C-CDK1-PLK1.
Rights: http://creativecommons.org/licenses/by/4.0/
Type: article
URI: http://hdl.handle.net/2115/63135
Appears in Collections:理学院・理学研究院 (Graduate School of Science / Faculty of Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 坂口 和靖

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