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Oral administration of the β-glucan produced by Aureobasidium pullulans ameliorates development of atherosclerosis in apolipoprotein E deficient mice

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Title: Oral administration of the β-glucan produced by Aureobasidium pullulans ameliorates development of atherosclerosis in apolipoprotein E deficient mice
Authors: Aoki, Shiho Browse this author
Iwai, Atsushi Browse this author
Kawata, Koji Browse this author
Muramatsu, Daisuke Browse this author
Uchiyama, Hirofumi Browse this author
Okabe, Mitsuyasu Browse this author
Ikesue, Masahiro Browse this author
Maeda, Naoyoshi Browse this author
Uede, Toshimitsu Browse this author →KAKEN DB
Keywords: β-glucan
Aureobasidium pullulans
Atherosclerosis
Issue Date: Oct-2015
Publisher: Elsevier
Journal Title: Journal of Functional Foods
Volume: 18
Start Page: 22
End Page: 27
Publisher DOI: 10.1016/j.jff.2015.06.044
Abstract: The Aureobasidium pullulans-produced β-glucan (AP-PG) is an immune stimulator, and believed to exhibit beneficial effects on health through its immune stimulating activity. Here, the effect of oral administration of AP-PG on high-fat diet (HFD)-induced atherosclerosis was evaluated using apolipoprotein E deficient mice, a widely used mouse model for atherosclerosis. The results demonstrated that HFD-induced development of atherosclerosis was significantly reduced in the AP-PG-treated mice when compared with that of the control mice. In serological analysis, blood levels of oxidized low-density lipoprotein cholesterol, a well-known risk factor for the development of atherosclerosis, were significantly reduced in the AP-PG-treated group of mice. Further, immunohistochemical analysis using MOMA-2 antibody showed that oral administration of AP-PG is effective in ameliorating vascular accumulation of macrophages. These data suggest the possibility that oral administration of AP-PG is effective in ameliorating HFD-induced development of atherosclerosis.
Rights: © 2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
http://creativecommons.org/licenses/by-nc-nd/4.0/
Type: article (author version)
URI: http://hdl.handle.net/2115/63473
Appears in Collections:遺伝子病制御研究所 (Institute for Genetic Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 岩井 淳

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