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Oral administration of the β-glucan produced by Aureobasidium pullulans ameliorates development of atherosclerosis in apolipoprotein E deficient mice

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タイトル: Oral administration of the β-glucan produced by Aureobasidium pullulans ameliorates development of atherosclerosis in apolipoprotein E deficient mice
著者: Aoki, Shiho 著作を一覧する
Iwai, Atsushi 著作を一覧する
Kawata, Koji 著作を一覧する
Muramatsu, Daisuke 著作を一覧する
Uchiyama, Hirofumi 著作を一覧する
Okabe, Mitsuyasu 著作を一覧する
Ikesue, Masahiro 著作を一覧する
Maeda, Naoyoshi 著作を一覧する
Uede, Toshimitsu 著作を一覧する
キーワード: β-glucan
Aureobasidium pullulans
Atherosclerosis
発行日: 2015年10月
出版者: Elsevier
誌名: Journal of Functional Foods
巻: 18
開始ページ: 22
終了ページ: 27
出版社 DOI: 10.1016/j.jff.2015.06.044
抄録: The Aureobasidium pullulans-produced β-glucan (AP-PG) is an immune stimulator, and believed to exhibit beneficial effects on health through its immune stimulating activity. Here, the effect of oral administration of AP-PG on high-fat diet (HFD)-induced atherosclerosis was evaluated using apolipoprotein E deficient mice, a widely used mouse model for atherosclerosis. The results demonstrated that HFD-induced development of atherosclerosis was significantly reduced in the AP-PG-treated mice when compared with that of the control mice. In serological analysis, blood levels of oxidized low-density lipoprotein cholesterol, a well-known risk factor for the development of atherosclerosis, were significantly reduced in the AP-PG-treated group of mice. Further, immunohistochemical analysis using MOMA-2 antibody showed that oral administration of AP-PG is effective in ameliorating vascular accumulation of macrophages. These data suggest the possibility that oral administration of AP-PG is effective in ameliorating HFD-induced development of atherosclerosis.
Rights: © 2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
資料タイプ: article (author version)
URI: http://hdl.handle.net/2115/63473
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 岩井 淳

 

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