HUSCAP logo Hokkaido Univ. logo

Hokkaido University Collection of Scholarly and Academic Papers >
獣医学研究科  >
雑誌発表論文等  >

A Nucleoside Anticancer Drug, 1-(3-C-Ethynyl-β-D-Ribo-Pentofuranosyl)Cytosine, Induces Depth-Dependent Enhancement of Tumor Cell Death in Spread-Out Bragg Peak (SOBP) of Proton Beam

この資料はクリエイティブ・コモンズ・ライセンスの下で公開されています。

フルテキスト
journal.pone.0166848.pdf2.52 MBPDF見る/開く
Supplemental data.pdf483.3 kBPDF見る/開く
この文献へのリンクには次のURLを使用してください:http://hdl.handle.net/2115/63679

タイトル: A Nucleoside Anticancer Drug, 1-(3-C-Ethynyl-β-D-Ribo-Pentofuranosyl)Cytosine, Induces Depth-Dependent Enhancement of Tumor Cell Death in Spread-Out Bragg Peak (SOBP) of Proton Beam
著者: Maeda, Kenichiro 著作を一覧する
Yasui, Hironobu 著作を一覧する
Yamamori, Tohru 著作を一覧する
Matsuura, Taeko 著作を一覧する
Takao, Seishin 著作を一覧する
Suzuki, Motofumi 著作を一覧する
Matsuda, Akira 著作を一覧する
Inanami, Osamu 著作を一覧する
Shirato, Hiroki 著作を一覧する
発行日: 2016年11月22日
出版者: The Public Library of Science
誌名: PLOS One
巻: 11
号: 11
開始ページ: e0166848
出版社 DOI: 10.1371/journal.pone.0166848
抄録: The effect of 1-(3-C-ethynyl-β-D-ribo-pentofuranosyl)cytosine (ECyd) on proton-induced cell death was evaluated in human lung carcinoma cell line A549 and Chinese hamster fibroblast cell line V79 to enhance relative biological effectiveness (RBE) within the spread-out Bragg peak (SOBP) of proton beams. Treatment with ECyd significantly enhanced the proton-induced loss of clonogenicity and increased senescence at the center, but not at the distal edge of SOBP. The p53-binding protein 1 foci formation assay showed that ECyd decelerated the rate of DNA double-strand break (DSB) repair at the center, but not the distal region of SOBP, suggesting that the ECyd-induced enhancement of proton-induced cell death is partially associated with the inhibition of DSB repair. This study demonstrated that ECyd enhances proton-induced cell killing at all positions of SOBP, except for the distal region and minimizes the site-dependent differences in RBE within SOBP. Thus, ECyd is a unique radiosensitizer for proton therapy that may be useful because it levels the biological dose within SOBP, which improves tumor control and reduces the risk of adverse effects at the distal edge of SOBP.
資料タイプ: article
URI: http://hdl.handle.net/2115/63679
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 稲波 修

 

本サイトに関するご意見・お問い合わせは repo at lib.hokudai.ac.jp へお願いします。 - 北海道大学