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Improvement of transcutaneous fluorescent images with a depth-dependent point-spread function
| Title: | Improvement of transcutaneous fluorescent images with a depth-dependent point-spread function |
| Authors: | Shimizu, Koichi1 Browse this author →KAKEN DB | | Koji, Tochio Browse this author | | Kato, Yuji Browse this author |
| Authors(alt): | 清水, 孝一1 |
| Keywords: | Image processing : Deconvolution | | Image processing : Image reconstruction-restoration | | Medical optics and biotechnology : Image reconstruction techniques | | Medical optics and biotechnology : Light propagation in tissues | | Medical optics and biotechnology : Medical and biological imaging | | Medical optics and biotechnology : Turbid media | | scattering | | fluorescence | | imaging | | molecular imaging | | transillumination imaging | | PSF |
| Issue Date: | Apr-2005 |
| Publisher: | Optical Society of America |
| Journal Title: | Applied Optics |
| Volume: | 44 |
| Issue: | 11 |
| Start Page: | 2154 |
| End Page: | 2161 |
| Publisher DOI: | 10.1364/AO.44.002154 |
| Abstract: | The point-spread function (PSF) for transcutaneous fluorescent imaging was obtained as an analytical solution in a closed form. It is applicable to cases in which the optical property of the image-blurring turbid medium is considered to be fairly homogeneous. We proposed a technique to improve a transcutaneous image by using depth-dependent PSF. Contrast of the fluorescent image was improved for depths of 1-15 mm in a scattering medium (µ_s' = 1/mm). The visible depth was more than doubled with this technique. An experiment with a rat demonstrated considerable improvement of a transcutaneous image of the cerebral vein at a specified depth. The spread image of the heart was reduced to the correct size by use of the PSF with the actual depth of the heart. |
| Rights: | (c) 2005 Optical Society of America |
| Type: | article |
| URI: | http://hdl.handle.net/2115/643 |
| Appears in Collections: | 情報科学院・情報科学研究院 (Graduate School of Information Science and Technology / Faculty of Information Science and Technology) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 清水 孝一
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