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Improvement of transcutaneous fluorescent images with a depth-dependent point-spread function

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Title: Improvement of transcutaneous fluorescent images with a depth-dependent point-spread function
Authors: Shimizu, Koichi1 Browse this author →KAKEN DB
Koji, Tochio Browse this author
Kato, Yuji Browse this author
Authors(alt): 清水, 孝一1
Keywords: Image processing : Deconvolution
Image processing : Image reconstruction-restoration
Medical optics and biotechnology : Image reconstruction techniques
Medical optics and biotechnology : Light propagation in tissues
Medical optics and biotechnology : Medical and biological imaging
Medical optics and biotechnology : Turbid media
scattering
fluorescence
imaging
molecular imaging
transillumination imaging
PSF
Issue Date: Apr-2005
Publisher: Optical Society of America
Journal Title: Applied Optics
Volume: 44
Issue: 11
Start Page: 2154
End Page: 2161
Publisher DOI: 10.1364/AO.44.002154
Abstract: The point-spread function (PSF) for transcutaneous fluorescent imaging was obtained as an analytical solution in a closed form. It is applicable to cases in which the optical property of the image-blurring turbid medium is considered to be fairly homogeneous. We proposed a technique to improve a transcutaneous image by using depth-dependent PSF. Contrast of the fluorescent image was improved for depths of 1-15 mm in a scattering medium (µ_s' = 1/mm). The visible depth was more than doubled with this technique. An experiment with a rat demonstrated considerable improvement of a transcutaneous image of the cerebral vein at a specified depth. The spread image of the heart was reduced to the correct size by use of the PSF with the actual depth of the heart.
Rights: (c) 2005 Optical Society of America
Type: article
URI: http://hdl.handle.net/2115/643
Appears in Collections:情報科学院・情報科学研究院 (Graduate School of Information Science and Technology / Faculty of Information Science and Technology) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 清水 孝一

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