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Clinical outcomes of stage I and IIA non-small cell lung cancer patients treated with stereotactic body radiotherapy using a real-time tumor-tracking radiotherapy system.

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/64432

Title: Clinical outcomes of stage I and IIA non-small cell lung cancer patients treated with stereotactic body radiotherapy using a real-time tumor-tracking radiotherapy system.
Authors: Katoh, Norio Browse this author →KAKEN DB
Soda, Itaru Browse this author
Tamamura, Hiroyasu Browse this author
Takahashi, Shotaro Browse this author
Uchinami, Yusuke Browse this author
Ishiyama, Hiromichi Browse this author
Ota, Kiyotaka Browse this author
Inoue, Tetsuya Browse this author →KAKEN DB
Onimaru, Rikiya Browse this author →KAKEN DB
Shibuya, Keiko Browse this author →KAKEN DB
Hayakawa, Kazushige Browse this author →KAKEN DB
Shirato, Hiroki Browse this author →KAKEN DB
Keywords: Stereotactic body radiotherapy
Non-small cell lung cancer
Real-time tumor-tracking radiotherapy
Gated radiotherapy
Image-guided radiotherapy
Issue Date: 5-Jan-2017
Publisher: BioMed Central
Journal Title: Radiation Oncology
Volume: 12
Start Page: 3
Publisher DOI: 10.1186/s13014-016-0742-3
Abstract: Purpose: To investigate the clinical outcomes of stage I and IIA non-small cell lung cancer (NSCLC) patients treated with stereotactic body radiotherapy (SBRT) using a real-time tumor-tracking radiotherapy (RTRT) system. Materials and methods: Patterns-of-care in SBRT using RTRT for histologically proven, peripherally located, stage I and IIA NSCLC was retrospectively investigated in four institutions by an identical clinical report format. Patterns-of-outcomes was also investigated in the same manner. Results: From September 2000 to April 2012, 283 patients with 286 tumors were identified. The median age was 78 years (52-90) and the maximum tumor diameters were 9 to 65 mm with a median of 24 mm. The calculated biologically effective dose (10) at the isocenter using the linear-quadratic model was from 66 Gy to 126 Gy with a median of 106 Gy. With a median follow-up period of 28 months (range 0-127), the overall survival rate for the entire group, for stage IA, and for stage IB + IIA was 75%, 79%, and 65% at 2 years, and 64%, 70%, and 50% at 3 years, respectively. In the multivariate analysis, the favorable predictive factor was female for overall survival. There were no differences between the clinical outcomes at the four institutions. Grade 2, 3, 4, and 5 radiation pneumonitis was experienced by 29 (10.2%), 9 (3.2%), 0, and 0 patients. The subgroup analyses revealed that compared to margins from gross tumor volume (GTV) to planning target volume (PTV) ≥ 10 mm, margins < 10 mm did not worsen the overall survival and local control rates, while reducing the risk of radiation pneumonitis. Conclusions: This multi-institutional retrospective study showed that the results were consistent with the recent patterns-of-care and patterns-of-outcome analysis of SBRT. A prospective study will be required to evaluate SBRT using a RTRT system with margins from GTV to PTV < 10mm.
Rights: https://creativecommons.org/licenses/by/4.0/
Type: article
URI: http://hdl.handle.net/2115/64432
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
国際連携研究教育局 : GI-CoRE (Global Institution for Collaborative Research and Education : GI-CoRE) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 加藤 徳雄

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