| Title: | Clinical outcomes of stage I and IIA non-small cell lung cancer patients treated with stereotactic body radiotherapy using a real-time tumor-tracking radiotherapy system. |
| Authors: | Katoh, Norio Browse this author →KAKEN DB |
| Soda, Itaru Browse this author |
| Tamamura, Hiroyasu Browse this author |
| Takahashi, Shotaro Browse this author |
| Uchinami, Yusuke Browse this author |
| Ishiyama, Hiromichi Browse this author |
| Ota, Kiyotaka Browse this author |
| Inoue, Tetsuya Browse this author →KAKEN DB |
| Onimaru, Rikiya Browse this author →KAKEN DB |
| Shibuya, Keiko Browse this author →KAKEN DB |
| Hayakawa, Kazushige Browse this author →KAKEN DB |
| Shirato, Hiroki Browse this author →KAKEN DB |
| Keywords: | Stereotactic body radiotherapy |
| Non-small cell lung cancer |
| Real-time tumor-tracking radiotherapy |
| Gated radiotherapy |
| Image-guided radiotherapy |
| Issue Date: | 5-Jan-2017 |
| Publisher: | BioMed Central |
| Journal Title: | Radiation Oncology |
| Volume: | 12 |
| Start Page: | 3 |
| Publisher DOI: | 10.1186/s13014-016-0742-3 |
| Abstract: | Purpose: To investigate the clinical outcomes of stage I and IIA non-small cell lung cancer (NSCLC) patients treated with stereotactic body radiotherapy (SBRT) using a real-time tumor-tracking radiotherapy (RTRT) system. Materials and methods: Patterns-of-care in SBRT using RTRT for histologically proven, peripherally located, stage I and IIA NSCLC was retrospectively investigated in four institutions by an identical clinical report format. Patterns-of-outcomes was also investigated in the same manner. Results: From September 2000 to April 2012, 283 patients with 286 tumors were identified. The median age was 78 years (52-90) and the maximum tumor diameters were 9 to 65 mm with a median of 24 mm. The calculated biologically effective dose (10) at the isocenter using the linear-quadratic model was from 66 Gy to 126 Gy with a median of 106 Gy. With a median follow-up period of 28 months (range 0-127), the overall survival rate for the entire group, for stage IA, and for stage IB + IIA was 75%, 79%, and 65% at 2 years, and 64%, 70%, and 50% at 3 years, respectively. In the multivariate analysis, the favorable predictive factor was female for overall survival. There were no differences between the clinical outcomes at the four institutions. Grade 2, 3, 4, and 5 radiation pneumonitis was experienced by 29 (10.2%), 9 (3.2%), 0, and 0 patients. The subgroup analyses revealed that compared to margins from gross tumor volume (GTV) to planning target volume (PTV) ≥ 10 mm, margins < 10 mm did not worsen the overall survival and local control rates, while reducing the risk of radiation pneumonitis. Conclusions: This multi-institutional retrospective study showed that the results were consistent with the recent patterns-of-care and patterns-of-outcome analysis of SBRT. A prospective study will be required to evaluate SBRT using a RTRT system with margins from GTV to PTV < 10mm. |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/64432 |
| Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
国際連携研究教育局 : GI-CoRE (Global Institution for Collaborative Research and Education : GI-CoRE) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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