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Clinical outcomes of stage I and IIA non-small cell lung cancer patients treated with stereotactic body radiotherapy using a real-time tumor-tracking radiotherapy system.

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タイトル: Clinical outcomes of stage I and IIA non-small cell lung cancer patients treated with stereotactic body radiotherapy using a real-time tumor-tracking radiotherapy system.
著者: Katoh, Norio 著作を一覧する
Soda, Itaru 著作を一覧する
Tamamura, Hiroyasu 著作を一覧する
Takahashi, Shotaro 著作を一覧する
Uchinami, Yusuke 著作を一覧する
Ishiyama, Hiromichi 著作を一覧する
Ota, Kiyotaka 著作を一覧する
Inoue, Tetsuya 著作を一覧する
Onimaru, Rikiya 著作を一覧する
Shibuya, Keiko 著作を一覧する
Hayakawa, Kazushige 著作を一覧する
Shirato, Hiroki 著作を一覧する
キーワード: Stereotactic body radiotherapy
Non-small cell lung cancer
Real-time tumor-tracking radiotherapy
Gated radiotherapy
Image-guided radiotherapy
発行日: 2017年 1月 5日
出版者: BioMed Central
誌名: Radiation Oncology
巻: 12
開始ページ: 3
出版社 DOI: 10.1186/s13014-016-0742-3
抄録: Purpose: To investigate the clinical outcomes of stage I and IIA non-small cell lung cancer (NSCLC) patients treated with stereotactic body radiotherapy (SBRT) using a real-time tumor-tracking radiotherapy (RTRT) system. Materials and methods: Patterns-of-care in SBRT using RTRT for histologically proven, peripherally located, stage I and IIA NSCLC was retrospectively investigated in four institutions by an identical clinical report format. Patterns-of-outcomes was also investigated in the same manner. Results: From September 2000 to April 2012, 283 patients with 286 tumors were identified. The median age was 78 years (52-90) and the maximum tumor diameters were 9 to 65 mm with a median of 24 mm. The calculated biologically effective dose (10) at the isocenter using the linear-quadratic model was from 66 Gy to 126 Gy with a median of 106 Gy. With a median follow-up period of 28 months (range 0-127), the overall survival rate for the entire group, for stage IA, and for stage IB + IIA was 75%, 79%, and 65% at 2 years, and 64%, 70%, and 50% at 3 years, respectively. In the multivariate analysis, the favorable predictive factor was female for overall survival. There were no differences between the clinical outcomes at the four institutions. Grade 2, 3, 4, and 5 radiation pneumonitis was experienced by 29 (10.2%), 9 (3.2%), 0, and 0 patients. The subgroup analyses revealed that compared to margins from gross tumor volume (GTV) to planning target volume (PTV) ≥ 10 mm, margins < 10 mm did not worsen the overall survival and local control rates, while reducing the risk of radiation pneumonitis. Conclusions: This multi-institutional retrospective study showed that the results were consistent with the recent patterns-of-care and patterns-of-outcome analysis of SBRT. A prospective study will be required to evaluate SBRT using a RTRT system with margins from GTV to PTV < 10mm.
資料タイプ: article
URI: http://hdl.handle.net/2115/64432
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 加藤 徳雄

 

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