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Caspase-dependent cleavage regulates protein levels of Epstein-Barr virus-derived latent membrane protein 1

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タイトル: Caspase-dependent cleavage regulates protein levels of Epstein-Barr virus-derived latent membrane protein 1
著者: Togi, Sumihito 著作を一覧する
Hatano, Yosuke 著作を一覧する
Muromoto, Ryuta 著作を一覧する
Kawanishi, Eri 著作を一覧する
Ikeda, Osamu 著作を一覧する
Hirashima, Koki 著作を一覧する
Kon, Shigeyuki 著作を一覧する
Kitai, Yuichi 著作を一覧する
Yasui, Teruhito 著作を一覧する
Oritani, Kenji 著作を一覧する
Matsuda, Tadashi 著作を一覧する
キーワード: caspase
degradation
EBV
LMP1
NF-kappa B activation
発行日: 2016年 3月
出版者: Wiley-Blackwell
誌名: FEBS Letters
巻: 590
号: 6
開始ページ: 808
終了ページ: 818
出版社 DOI: 10.1002/1873-3468.12119
抄録: Epstein-Barr virus (EBV)-encoded latent membrane protein-1 (LMP1) plays pathogenic roles in EBV-related diseases. Thus, host cells employ several mechanisms to regulate LMP1 functions, and we previously reported possible regulation by signal transducing adaptor protein-2 as well as BS69. Here, we found that caspase-3 mainly degraded LMP1 proteins in HeLa cells, leading to decreased NF-kappa B and STAT3 activation. Caspase-3 cleaved the consensus DNTD sequences in the CTAR3 region of LMP1. Of importance, LMP1 expression strongly enhanced caspase-3 activity. Taken together, the reduction of LMP1 protein levels by caspases is likely to be a newly identified host defense against EBV infection.
Rights: This is the peer reviewed version of the following article: Caspase-dependent cleavage regulates protein levels of Epstein-Barr virus-derived latent membrane protein 1, FEBS Letters590(6), pp808-818, 2016, which has been published in final form at 10.1002/1873-3468.12119. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
資料タイプ: article (author version)
URI: http://hdl.handle.net/2115/64895
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 松田 正

 

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