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Caspase-dependent cleavage regulates protein levels of Epstein-Barr virus-derived latent membrane protein 1
Title: | Caspase-dependent cleavage regulates protein levels of Epstein-Barr virus-derived latent membrane protein 1 |
Authors: | Togi, Sumihito Browse this author | Hatano, Yosuke Browse this author | Muromoto, Ryuta Browse this author →KAKEN DB | Kawanishi, Eri Browse this author | Ikeda, Osamu Browse this author | Hirashima, Koki Browse this author | Kon, Shigeyuki Browse this author →KAKEN DB | Kitai, Yuichi Browse this author →KAKEN DB | Yasui, Teruhito Browse this author →KAKEN DB | Oritani, Kenji Browse this author →KAKEN DB | Matsuda, Tadashi Browse this author →KAKEN DB |
Keywords: | caspase | degradation | EBV | LMP1 | NF-kappa B activation |
Issue Date: | Mar-2016 |
Publisher: | Wiley-Blackwell |
Journal Title: | FEBS Letters |
Volume: | 590 |
Issue: | 6 |
Start Page: | 808 |
End Page: | 818 |
Publisher DOI: | 10.1002/1873-3468.12119 |
PMID: | 26921582 |
Abstract: | Epstein-Barr virus (EBV)-encoded latent membrane protein-1 (LMP1) plays pathogenic roles in EBV-related diseases. Thus, host cells employ several mechanisms to regulate LMP1 functions, and we previously reported possible regulation by signal transducing adaptor protein-2 as well as BS69. Here, we found that caspase-3 mainly degraded LMP1 proteins in HeLa cells, leading to decreased NF-kappa B and STAT3 activation. Caspase-3 cleaved the consensus DNTD sequences in the CTAR3 region of LMP1. Of importance, LMP1 expression strongly enhanced caspase-3 activity. Taken together, the reduction of LMP1 protein levels by caspases is likely to be a newly identified host defense against EBV infection. |
Rights: | This is the peer reviewed version of the following article: Caspase-dependent cleavage regulates protein levels of Epstein-Barr virus-derived latent membrane protein 1, FEBS Letters590(6), pp808-818, 2016, which has been published in final form at 10.1002/1873-3468.12119. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. |
Type: | article (author version) |
URI: | http://hdl.handle.net/2115/64895 |
Appears in Collections: | 薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 松田 正
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