HUSCAP logo Hokkaido Univ. logo

Hokkaido University Collection of Scholarly and Academic Papers >
Faculty of Pharmaceutical Sciences >
Peer-reviewed Journal Articles, etc >

Caspase-dependent cleavage regulates protein levels of Epstein-Barr virus-derived latent membrane protein 1

Files in This Item:
manuscript.pdf2.1 MBPDFView/Open
suppl.pdfSummplementary information169.11 kBPDFView/Open
Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/64895

Title: Caspase-dependent cleavage regulates protein levels of Epstein-Barr virus-derived latent membrane protein 1
Authors: Togi, Sumihito Browse this author
Hatano, Yosuke Browse this author
Muromoto, Ryuta Browse this author →KAKEN DB
Kawanishi, Eri Browse this author
Ikeda, Osamu Browse this author
Hirashima, Koki Browse this author
Kon, Shigeyuki Browse this author →KAKEN DB
Kitai, Yuichi Browse this author →KAKEN DB
Yasui, Teruhito Browse this author →KAKEN DB
Oritani, Kenji Browse this author →KAKEN DB
Matsuda, Tadashi Browse this author →KAKEN DB
Keywords: caspase
degradation
EBV
LMP1
NF-kappa B activation
Issue Date: Mar-2016
Publisher: Wiley-Blackwell
Journal Title: FEBS Letters
Volume: 590
Issue: 6
Start Page: 808
End Page: 818
Publisher DOI: 10.1002/1873-3468.12119
PMID: 26921582
Abstract: Epstein-Barr virus (EBV)-encoded latent membrane protein-1 (LMP1) plays pathogenic roles in EBV-related diseases. Thus, host cells employ several mechanisms to regulate LMP1 functions, and we previously reported possible regulation by signal transducing adaptor protein-2 as well as BS69. Here, we found that caspase-3 mainly degraded LMP1 proteins in HeLa cells, leading to decreased NF-kappa B and STAT3 activation. Caspase-3 cleaved the consensus DNTD sequences in the CTAR3 region of LMP1. Of importance, LMP1 expression strongly enhanced caspase-3 activity. Taken together, the reduction of LMP1 protein levels by caspases is likely to be a newly identified host defense against EBV infection.
Rights: This is the peer reviewed version of the following article: Caspase-dependent cleavage regulates protein levels of Epstein-Barr virus-derived latent membrane protein 1, FEBS Letters590(6), pp808-818, 2016, which has been published in final form at 10.1002/1873-3468.12119. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Type: article (author version)
URI: http://hdl.handle.net/2115/64895
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 松田 正

Export metadata:

OAI-PMH ( junii2 , jpcoar )

MathJax is now OFF:


 

Feedback - Hokkaido University