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Immunogenic cancer cell death selectively induced by near infrared photoimmunotherapy initiates host tumor immunity

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Title: Immunogenic cancer cell death selectively induced by near infrared photoimmunotherapy initiates host tumor immunity
Authors: Ogawa, Mikako Browse this author →KAKEN DB
Tomita, Yusuke Browse this author
Nakamura, Yuko Browse this author
Lee, Min-Jung Browse this author
Lee, Sunmin Browse this author
Tomita, Saori Browse this author
Nagaya, Tadanobu Browse this author
Sato, Kazuhide Browse this author
Yamauchi, Toyohiko Browse this author
Iwai, Hidenao Browse this author
Kumar, Abhishek Browse this author
Haystead, Timothy Browse this author
Shroff, Hari Browse this author
Choyke, Peter L. Browse this author
Trepel, Jane B. Browse this author
Kobayashi, Hisataka Browse this author
Keywords: near infrared photoimmunotherapy
immunogenic cell death
Issue Date: 20-Apr-2017
Publisher: Impact Journals
Journal Title: Oncotarget
Volume: 8
Issue: 6
Start Page: 10425
End Page: 10436
Publisher DOI: 10.18632/oncotarget.14425
Abstract: Immunogenic cell death (ICD) is a form of cell death that activates an adaptive immune response against dead-cell-associated antigens. Cancer cells killed via ICD can elicit antitumor immunity. ICD is efficiently induced by near-infrared photo-immunotherapy (NIR-PIT) that selectively kills target-cells on which antibody-photoabsorber conjugates bind and are activated by NIR light exposure. Advanced live cell microscopies showed that NIR-PIT caused rapid and irreversible damage to the cell membrane function leading to swelling and bursting, releasing intracellular components due to the influx of water into the cell. The process also induces relocation of ICD bio markers including calreticulin, Hsp70 and Hsp90 to the cell surface and the rapid release of immunogenic signals including ATP and HMGB1 followed by maturation of immature dendritic cells. Thus, NIR-PIT is a therapy that kills tumor cells by ICD, eliciting a host immune response against tumor.
Type: article
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 小川 美香子

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