| Title: | Immunogenic cancer cell death selectively induced by near infrared photoimmunotherapy initiates host tumor immunity |
| Authors: | Ogawa, Mikako Browse this author →KAKEN DB |
| Tomita, Yusuke Browse this author |
| Nakamura, Yuko Browse this author |
| Lee, Min-Jung Browse this author |
| Lee, Sunmin Browse this author |
| Tomita, Saori Browse this author |
| Nagaya, Tadanobu Browse this author |
| Sato, Kazuhide Browse this author |
| Yamauchi, Toyohiko Browse this author |
| Iwai, Hidenao Browse this author |
| Kumar, Abhishek Browse this author |
| Haystead, Timothy Browse this author |
| Shroff, Hari Browse this author |
| Choyke, Peter L. Browse this author |
| Trepel, Jane B. Browse this author |
| Kobayashi, Hisataka Browse this author |
| Keywords: | near infrared photoimmunotherapy |
| immunogenic cell death |
| Issue Date: | 20-Apr-2017 |
| Publisher: | Impact Journals |
| Journal Title: | Oncotarget |
| Volume: | 8 |
| Issue: | 6 |
| Start Page: | 10425 |
| End Page: | 10436 |
| Publisher DOI: | 10.18632/oncotarget.14425 |
| Abstract: | Immunogenic cell death (ICD) is a form of cell death that activates an adaptive immune response against dead-cell-associated antigens. Cancer cells killed via ICD can elicit antitumor immunity. ICD is efficiently induced by near-infrared photo-immunotherapy (NIR-PIT) that selectively kills target-cells on which antibody-photoabsorber conjugates bind and are activated by NIR light exposure. Advanced live cell microscopies showed that NIR-PIT caused rapid and irreversible damage to the cell membrane function leading to swelling and bursting, releasing intracellular components due to the influx of water into the cell. The process also induces relocation of ICD bio markers including calreticulin, Hsp70 and Hsp90 to the cell surface and the rapid release of immunogenic signals including ATP and HMGB1 followed by maturation of immature dendritic cells. Thus, NIR-PIT is a therapy that kills tumor cells by ICD, eliciting a host immune response against tumor. |
| Rights: | http://creativecommons.org/licenses/by/3.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/65122 |
| Appears in Collections: | 薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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