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Dissociation of the neural substrates of foraging effort and its social facilitation in the domestic chick

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Title: Dissociation of the neural substrates of foraging effort and its social facilitation in the domestic chick
Authors: Ogura, Yukiko Browse this author
Izumi, Takeshi Browse this author →KAKEN DB
Yoshioka, Mitsuhiro Browse this author →KAKEN DB
Matsushima, Toshiya Browse this author →KAKEN DB
Keywords: Dopamine
Incentive motivation
Ventral tegmental area
Substantia nigra
Ventral striatum
Nucleus accumbens
Issue Date: 1-Nov-2015
Publisher: Elsevier
Journal Title: Behavioural Brain Research
Volume: 294
Start Page: 162
End Page: 176
Publisher DOI: 10.1016/j.bbr.2015.07.052
PMID: 26235329
Abstract: The frequency or intensity of behavior is often facilitated by the presence of others. This social facilitation has been reported in a variety of animals, including birds and humans. Based on Zajonc’s “drive theory,” we hypothesized that facilitation and drive have shared neural mechanisms, and that dopaminergic projections from the midbrain to striatum are involved. As the ascending dopaminergic projections include the mesolimbic and nigrostriatal pathways, we targeted our lesions at the medial striatum (MSt) and substantia nigra (SN). We found that a bilateral electrolytic lesion of the MSt suppressed baseline foraging effort, but social facilitation was intact. Conversely, an electrolytic lesion targeted at the unilateral SN (on the right side) partially suppressed social facilitation, while baseline foraging effort remained unaffected. However, selective depletion of catecholaminergic (thyrosine hydroxylase immunoreactive) terminals by micro-infusion of 6-hydroxydopamine (6-OHDA) to bilateral MSt had no significant effects on foraging behavior, whereas it impaired formation of the association memory reinforced by water reward. Neurochemical assay by high-perfromance liquid chromatography also revealed a significant decrease in the dopamine and noradrenaline contents in MSt after 6-OHDA micro-infusion compared with intact control chicks. Thus, we conclude that the neural substrate of social facilitation can be dissociated from that responsible for reward-based foraging effort, and that ascending dopaminergic pathways do not appear to contribute to social facilitation. Based on our detailed analysis of the lesion areas, we discuss fiber tracts or neural components of the midbrain tegmental area that may be responsible for social facilitation.
Rights: ©2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
Type: article (author version)
Appears in Collections:理学院・理学研究院 (Graduate School of Science / Faculty of Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 松島 俊也

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