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Rhodium-Catalyzed Enantioselective Arylation of Aliphatic Imines
| Title: | Rhodium-Catalyzed Enantioselective Arylation of Aliphatic Imines |
| Authors: | Kato, Naoya Browse this author | | Shirai, Tomohiko Browse this author | | Yamamoto, Yasunori Browse this author →KAKEN DB |
| Keywords: | asymmetric arylation | | cationic rhodium | | imines | | phosphoramidite | | alpha-branched amine |
| Issue Date: | 1-Jun-2016 |
| Publisher: | Wiley-Blackwell |
| Journal Title: | Chemistry-A European journal |
| Volume: | 22 |
| Issue: | 23 |
| Start Page: | 7739 |
| End Page: | 7742 |
| Publisher DOI: | 10.1002/chem.201601246 |
| PMID: | 27119262 |
| Abstract: | Chiral rhodium(I)-catalyzed highly enantioselective arylation of aliphatic N-sulfonyl aldimines with arylboronic acids has been developed. This transformation is achieved by the use of a rhodium/bis(phosphoramidite) catalyst to give enantiomerically enriched a-branched amines (up to 99% ee). In addition, this system enables efficient synthesis of (+)-NPS R-568 and Cinacalcet which are calcimimetic agents. |
| Rights: | This is the peer reviewed version of the following article: Chemistry A European journal, 22(23) June 1 2016 Pages 7739–7742 , which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1002/chem.201601246/abstract. This article may be used for non-commercial purposes in accordance With Wiley-VCH Terms and Conditions for self-archiving. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/65861 |
| Appears in Collections: | 工学院・工学研究院 (Graduate School of Engineering / Faculty of Engineering) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 山本 靖典
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