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Unveiling the Biosynthetic Pathway of the Ribosomally Synthesized and Post-translationally Modified Peptide Ustiloxin B in Filamentous Fungi

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Title: Unveiling the Biosynthetic Pathway of the Ribosomally Synthesized and Post-translationally Modified Peptide Ustiloxin B in Filamentous Fungi
Authors: Ye, Ying Browse this author
Minami, Atsushi Browse this author
Igarashi, Yuya Browse this author
Izumikawa, Miho Browse this author
Umemura, Myco Browse this author
Nagano, Nozomi Browse this author
Machida, Masayuki Browse this author
Kawahara, Teppei Browse this author
Shin-ya, Kazuo Browse this author
Gomi, Katsuya Browse this author
Oikawa, Hideaki Browse this author →KAKEN DB
Keywords: biosynthesis
heterologous expression
natural products
RiPPs
ustiloxins
Issue Date: 4-Jul-2016
Publisher: Wiley-Blackwell
Journal Title: Angewandte chemie-international edition
Volume: 55
Issue: 28
Start Page: 8072
End Page: 8075
Publisher DOI: 10.1002/anie.201602611
PMID: 27166860
Abstract: The biosynthetic machinery of the first fungal ribosomally synthesized and post-translationally modified peptide (RiPP) ustiloxin B was elucidated through a series of gene inactivation and heterologous expression studies. The results confirmed an essential requirement for novel oxidases possessing the DUF3328 motif for macrocyclization, and highly unique side-chain modifications by three oxidases (UstCF1F2) and a pyridoxal 5'-phosphate (PLP)-dependent enzyme (UstD). These findings provide new insight into the expression of the RiPP gene clusters found in various fungi.
Rights: This is the peer reviewed version of the following article: Y. Ye, A. Minami, Y. Igarashi, M. Izumikawa, M. Umemura, N. Nagano, M. Machida, T. Kawahara, K. Shin-ya, K. Gomi, H. Oikawa, Angew. Chem. Int. Ed. 2016, 55, 8072, which has been published in final form at doi:10.1002/anie.201602611. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Type: article (author version)
URI: http://hdl.handle.net/2115/66438
Appears in Collections:理学院・理学研究院 (Graduate School of Science / Faculty of Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 及川 英秋

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