Title: | Unveiling the Biosynthetic Pathway of the Ribosomally Synthesized and Post-translationally Modified Peptide Ustiloxin B in Filamentous Fungi |
Authors: | Ye, Ying Browse this author |
Minami, Atsushi Browse this author |
Igarashi, Yuya Browse this author |
Izumikawa, Miho Browse this author |
Umemura, Myco Browse this author |
Nagano, Nozomi Browse this author |
Machida, Masayuki Browse this author |
Kawahara, Teppei Browse this author |
Shin-ya, Kazuo Browse this author |
Gomi, Katsuya Browse this author |
Oikawa, Hideaki Browse this author →KAKEN DB |
Keywords: | biosynthesis |
heterologous expression |
natural products |
RiPPs |
ustiloxins |
Issue Date: | 4-Jul-2016 |
Publisher: | Wiley-Blackwell |
Journal Title: | Angewandte chemie-international edition |
Volume: | 55 |
Issue: | 28 |
Start Page: | 8072 |
End Page: | 8075 |
Publisher DOI: | 10.1002/anie.201602611 |
PMID: | 27166860 |
Abstract: | The biosynthetic machinery of the first fungal ribosomally synthesized and post-translationally modified peptide (RiPP) ustiloxin B was elucidated through a series of gene inactivation and heterologous expression studies. The results confirmed an essential requirement for novel oxidases possessing the DUF3328 motif for macrocyclization, and highly unique side-chain modifications by three oxidases (UstCF1F2) and a pyridoxal 5'-phosphate (PLP)-dependent enzyme (UstD). These findings provide new insight into the expression of the RiPP gene clusters found in various fungi. |
Rights: | This is the peer reviewed version of the following article: Y. Ye, A. Minami, Y. Igarashi, M. Izumikawa, M. Umemura, N. Nagano, M. Machida, T. Kawahara, K. Shin-ya, K. Gomi, H. Oikawa, Angew. Chem. Int. Ed. 2016, 55, 8072, which has been published in final form at doi:10.1002/anie.201602611. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. |
Type: | article (author version) |
URI: | http://hdl.handle.net/2115/66438 |
Appears in Collections: | 理学院・理学研究院 (Graduate School of Science / Faculty of Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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