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Regulation of the Physiological Function and Metabolism of AβPP by AβPP Binding Proteins

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Title: Regulation of the Physiological Function and Metabolism of AβPP by AβPP Binding Proteins
Authors: Taru, Hidenori Browse this author →KAKEN DB
Suzuki, Toshiharu Browse this author
Bissette, Garth Browse this author
Issue Date: 26-Aug-2009
Publisher: IOS Press
Journal Title: Journal of Alzheimer's Disease
Volume: 18
Issue: 2
Start Page: 253
End Page: 265
Publisher DOI: 10.3233/JAD-2009-1148
PMID: 19584434
Abstract: β-Amyloid precursor protein (APP) is a receptor-like, type-I membrane protein that plays a central role in the pathogenesis of Alzheimer’s disease. The cytoplasmic domain of APP is important for the metabolism and physiological functions of APP. The cytoplasmic domain contains a GYENPTY motif that interacts with proteins that contain a phosphotyrosine binding (PTB) domain such as X11/Mint, FE65, and the JIP family of proteins. X11 and X11-like proteins are neuronal adaptor proteins involved in presynaptic function and the intracellular trafficking of proteins. Recent studies in X11s knock-out mice confirmed findings from in vitro studies that X11 proteins affect APP metabolism and the generation of β-amyloid peptide. FE65 proteins are involved in transactivation in coordination with the intracellular domain fragment of APP, and/or in cellular responses to DNA damage. Neurodevelopmental defects observed in FE65s double knockout mice suggest that FE65 proteins cooperate with APP to play a role in neuronal cytoskeletal regulation. c-Jun N-terminal kinase (JNK) interacting protein-1 (JIP-1), a scaffolding protein for the JNK kinase cascade, has been suggested to mediate the intracellular trafficking of APP by molecular motor kinesin-1. This article reviews some of the recent findings regarding the regulation of physiological function and metabolism of APP by APP binding proteins.
Rights: The final publication is available at IOS Press through http://dx.doi.org/10.3233/JAD-2009-1148
Type: article (author version)
URI: http://hdl.handle.net/2115/66563
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 多留 偉功

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