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Isolation of rugosin A, B and related compounds as dipeptidyl peptidase-IV inhibitors from rose bud extract powder

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Biosci. Biotechnol. Biochem.80-11_2087-2092.pdf425.91 kBPDFView/Open
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Title: Isolation of rugosin A, B and related compounds as dipeptidyl peptidase-IV inhibitors from rose bud extract powder
Authors: Kato, Eisuke Browse this author →KAKEN DB
Uenishi, Yuta Browse this author
Inagaki, Yosuke Browse this author
Kurokawa, Mihoko Browse this author
Kawabata, Jun Browse this author →KAKEN DB
Keywords: dipeptidyl peptidase IV
Rosa gallica
Issue Date: Aug-2016
Publisher: Taylor & Francis
Journal Title: Bioscience biotechnology and biochemistry
Volume: 80
Issue: 11
Start Page: 2087
End Page: 2092
Publisher DOI: 10.1080/09168451.2016.1214533
PMID: 27477520
Abstract: Dipeptidyl peptidase-IV (DPP-IV) is a protease responsible for the degradation of the incretin hormone. A number of DPP-IV inhibitors have been approved for use in the treatment of type 2 diabetes. While these inhibitors are effective for this treatment, methods for the prevention of this disease are also required as diabetes patient numbers are currently increasing rapidly worldwide. We screened the DPP-IV inhibitory activities of edible plant extracts with the intention of using these extracts in a functional food supplement for the prevention of diabetes. Rose (Rosa gallica) bud extract powder was a promising material with high inhibitory activity. In this study, seven ellagitannins were isolated as active compounds through activity-guided fractionations, and their DPP-IV inhibitory activities were measured. Among them, rugosin A and B showed the highest inhibitory activities and rugosin B was shown as the major contributing compound in rose bud extract powder.
Rights: This is an Accepted Manuscript of an article published by Taylor & Francis in Bioscience biotechnology and biochemistry on 01 Aug 2016, available online: /09168451.2016.1214533
Type: article (author version)
Appears in Collections:農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 加藤 英介

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