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Side-scattered finger-photoplethysmography: experimental investigations toward practical noninvasive measurement of blood glucose

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Title: Side-scattered finger-photoplethysmography: experimental investigations toward practical noninvasive measurement of blood glucose
Authors: Yamakoshi, Yasuhiro Browse this author
Matsumura, Kenta Browse this author
Yamakoshi, Takehiro Browse this author
Lee, Jihyoung Browse this author
Rolfe, Peter Browse this author
Kato, Yuji Browse this author →KAKEN DB
Shimizu, Koichi Browse this author →KAKEN DB
Yamakoshi, Ken-ichi Browse this author
Keywords: side-scattered radiation
laser diode
finger-photoplethysmography
water absorption
blood glucose absorption
pulse glucometry
Issue Date: Jun-2017
Publisher: Society of Photo-Optical Instrumentation Engineers (SPIE)
Journal Title: Journal of biomedical optics
Volume: 22
Issue: 6
Start Page: 67001
Publisher DOI: 10.1117/1.JBO.22.6.067001
PMID: 28636064
Abstract: The aim of this study was to discover a simple/convenient geometrical arrangement of radiation sources and detector to acquire finger-photoplethysmograms (PPGs) with wavelength regions of blood glucose (BGL) absorption, toward practical noninvasive BGL measurement. First, we compared PPGs with three wavelengths: 808 nm (without water absorption), 1160 nm (with weak water absorption), and 1600 nm (with nearly peak BGL absorption and strong water absorption), while the source-detector spacing was successively increased circumferentially around a fingertip. In 10 healthy subjects, we observed clear cardiac-related pulsatile components of PPG signals at 808 and 1160 nm in any incident positions with more than 15 dB of signal-to-noise ratio (S/N), but reliable PPG detections at 1600 nm with more than 10 dB of S/N was only possible when the source-detector distance was less than 3mm around the fingertip circumference. Second, with this arrangement, an experiment was performed using six wavelengths to cover glucose absorption bands (from 1550 to 1749 nm), obtaining pulsatile PPG signals with more or less 15 dB of S/N. Through the present experiments, this orthogonal arrangement of the source and detector to detect forward-and side-scattered radiation through the tissue is appropriate for PPG measurements with wavelength regions where there is potential for BGL measurement.
Rights: Copyright 2017. Society of Photo Optical Instrumentation Engineers. One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.
https://creativecommons.org/licenses/by/3.0/
Type: article
URI: http://hdl.handle.net/2115/67038
Appears in Collections:情報科学院・情報科学研究院 (Graduate School of Information Science and Technology / Faculty of Information Science and Technology) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 山越 康弘

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