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The immunosuppressive effect of domain-deleted dimer of HLA-G2 isoform in collagen-induced arthritis mice
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Title: | The immunosuppressive effect of domain-deleted dimer of HLA-G2 isoform in collagen-induced arthritis mice |
Authors: | Takahashi, Ami Browse this author | Kuroki, Kimiko Browse this author →KAKEN DB | Okabe, Yuki Browse this author | Kasai, Yoshiyuki Browse this author | Matsumoto, Naoki Browse this author | Yamada, Chisato Browse this author | Takai, Toshiyuki Browse this author →KAKEN DB | Ose, Toyoyuki Browse this author →KAKEN DB | Kon, Shigeyuki Browse this author →KAKEN DB | Matsuda, Tadashi Browse this author →KAKEN DB | Maenaka, Katsumi Browse this author →KAKEN DB |
Keywords: | HLA-G2 | LILRB2/ILT4 | PIR-B | CIA mice | Immunosuppression |
Issue Date: | Sep-2016 |
Publisher: | Elsevier |
Journal Title: | Human immunology |
Volume: | 77 |
Issue: | 9 |
Start Page: | 754 |
End Page: | 759 |
Publisher DOI: | 10.1016/j.humimm.2016.01.010 |
PMID: | 26805457 |
Abstract: | HLA-G is involved in maternal-fetal immune tolerance and is reported to be a natural tolerogenic molecule. Seven-spliced isoforms including dimeric and beta 2m-free forms have been identified. The major isoform, HLA-G1 (and its soluble type HLA-G5), binds to the inhibitory immune receptors, leukocyte immunoglobulin (Ig)-like receptor (LILR) B1 and LILRB2. We previously reported that HLA-G1 also binds to paired Ig-like receptor (PIR)-B, a mouse homolog of LILRBs, and had a significant immunosuppressive effect in collagen-induced arthritis (CIA) mice. Although HLA-G2 and its soluble form HLA-G6 bind specifically to LILRB2, its functional characteristics are largely unknown. In this study, we report the significant immunosuppressive effect of HLA-G2 dimer in CIA mice. Surface plasmon resonance analysis revealed a specific interaction of HLA-G2 with PIR-B. CIA mice were administered HLA-G2 protein subcutaneously once in the left footpad and clinical severity was evaluated in a double-blind study. A single administration of HLA-G2 maintained a suppressive effect for over 1 month. These results suggested that the HLA-G2 protein might be a useful biopharmaceutical for the treatment of rheumatoid arthritis by binding to inhibitory PIR-B. (C) 2016 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved. |
Rights: | © 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | https://creativecommons.org/licenses/by-nc-nd/4.0/ |
Type: | article (author version) |
URI: | http://hdl.handle.net/2115/67073 |
Appears in Collections: | 薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 黒木 喜美子
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