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The immunosuppressive effect of domain-deleted dimer of HLA-G2 isoform in collagen-induced arthritis mice

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タイトル: The immunosuppressive effect of domain-deleted dimer of HLA-G2 isoform in collagen-induced arthritis mice
著者: Takahashi, Ami 著作を一覧する
Kuroki, Kimiko 著作を一覧する
Okabe, Yuki 著作を一覧する
Kasai, Yoshiyuki 著作を一覧する
Matsumoto, Naoki 著作を一覧する
Yamada, Chisato 著作を一覧する
Takai, Toshiyuki 著作を一覧する
Ose, Toyoyuki 著作を一覧する
Kon, Shigeyuki 著作を一覧する
Matsuda, Tadashi 著作を一覧する
Maenaka, Katsumi 著作を一覧する
キーワード: HLA-G2
LILRB2/ILT4
PIR-B
CIA mice
Immunosuppression
発行日: 2016年 9月
出版者: Elsevier
誌名: Human immunology
巻: 77
号: 9
開始ページ: 754
終了ページ: 759
出版社 DOI: 10.1016/j.humimm.2016.01.010
抄録: HLA-G is involved in maternal-fetal immune tolerance and is reported to be a natural tolerogenic molecule. Seven-spliced isoforms including dimeric and beta 2m-free forms have been identified. The major isoform, HLA-G1 (and its soluble type HLA-G5), binds to the inhibitory immune receptors, leukocyte immunoglobulin (Ig)-like receptor (LILR) B1 and LILRB2. We previously reported that HLA-G1 also binds to paired Ig-like receptor (PIR)-B, a mouse homolog of LILRBs, and had a significant immunosuppressive effect in collagen-induced arthritis (CIA) mice. Although HLA-G2 and its soluble form HLA-G6 bind specifically to LILRB2, its functional characteristics are largely unknown. In this study, we report the significant immunosuppressive effect of HLA-G2 dimer in CIA mice. Surface plasmon resonance analysis revealed a specific interaction of HLA-G2 with PIR-B. CIA mice were administered HLA-G2 protein subcutaneously once in the left footpad and clinical severity was evaluated in a double-blind study. A single administration of HLA-G2 maintained a suppressive effect for over 1 month. These results suggested that the HLA-G2 protein might be a useful biopharmaceutical for the treatment of rheumatoid arthritis by binding to inhibitory PIR-B. (C) 2016 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.
Rights: © 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
資料タイプ: article (author version)
URI: http://hdl.handle.net/2115/67073
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 黒木 喜美子

 

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