HUSCAP logo Hokkaido Univ. logo

Hokkaido University Collection of Scholarly and Academic Papers >
Faculty of Pharmaceutical Sciences >
Peer-reviewed Journal Articles, etc >

The immunosuppressive effect of domain-deleted dimer of HLA-G2 isoform in collagen-induced arthritis mice

Creative Commons License

Files in This Item:
manuscript.pdf617.6 kBPDFView/Open
Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/67073

Title: The immunosuppressive effect of domain-deleted dimer of HLA-G2 isoform in collagen-induced arthritis mice
Authors: Takahashi, Ami Browse this author
Kuroki, Kimiko Browse this author →KAKEN DB
Okabe, Yuki Browse this author
Kasai, Yoshiyuki Browse this author
Matsumoto, Naoki Browse this author
Yamada, Chisato Browse this author
Takai, Toshiyuki Browse this author →KAKEN DB
Ose, Toyoyuki Browse this author →KAKEN DB
Kon, Shigeyuki Browse this author →KAKEN DB
Matsuda, Tadashi Browse this author →KAKEN DB
Maenaka, Katsumi Browse this author →KAKEN DB
Keywords: HLA-G2
LILRB2/ILT4
PIR-B
CIA mice
Immunosuppression
Issue Date: Sep-2016
Publisher: Elsevier
Journal Title: Human immunology
Volume: 77
Issue: 9
Start Page: 754
End Page: 759
Publisher DOI: 10.1016/j.humimm.2016.01.010
PMID: 26805457
Abstract: HLA-G is involved in maternal-fetal immune tolerance and is reported to be a natural tolerogenic molecule. Seven-spliced isoforms including dimeric and beta 2m-free forms have been identified. The major isoform, HLA-G1 (and its soluble type HLA-G5), binds to the inhibitory immune receptors, leukocyte immunoglobulin (Ig)-like receptor (LILR) B1 and LILRB2. We previously reported that HLA-G1 also binds to paired Ig-like receptor (PIR)-B, a mouse homolog of LILRBs, and had a significant immunosuppressive effect in collagen-induced arthritis (CIA) mice. Although HLA-G2 and its soluble form HLA-G6 bind specifically to LILRB2, its functional characteristics are largely unknown. In this study, we report the significant immunosuppressive effect of HLA-G2 dimer in CIA mice. Surface plasmon resonance analysis revealed a specific interaction of HLA-G2 with PIR-B. CIA mice were administered HLA-G2 protein subcutaneously once in the left footpad and clinical severity was evaluated in a double-blind study. A single administration of HLA-G2 maintained a suppressive effect for over 1 month. These results suggested that the HLA-G2 protein might be a useful biopharmaceutical for the treatment of rheumatoid arthritis by binding to inhibitory PIR-B. (C) 2016 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.
Rights: © 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
https://creativecommons.org/licenses/by-nc-nd/4.0/
Type: article (author version)
URI: http://hdl.handle.net/2115/67073
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 黒木 喜美子

Export metadata:

OAI-PMH ( junii2 , jpcoar )

MathJax is now OFF:


 

Feedback - Hokkaido University