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Three-day regimen of oseltamivir for postexposure prophylaxis of influenza in wards

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Title: Three-day regimen of oseltamivir for postexposure prophylaxis of influenza in wards
Other Titles: Three-day regimen of oseltamivir for post-exposure prophylaxis of influenza in wards
Authors: Ishiguro, N. Browse this author →KAKEN DB
Oyamada, R. Browse this author
Nasuhara, Y. Browse this author
Yamada, T. Browse this author
Miyamoto, T. Browse this author
Imai, S. Browse this author
Akizawa, K. Browse this author
Fukumoto, T. Browse this author
Iwasaki, S. Browse this author
Iijima, H. Browse this author
Ono, K. Browse this author
Keywords: Influenza
Postexposure prophylaxis
Oseltamivir
Post-exposure prophylaxis
Issue Date: Oct-2016
Publisher: Elsevier
Journal Title: Journal of hospital infection
Volume: 94
Issue: 2
Start Page: 150
End Page: 153
Publisher DOI: 10.1016/j.jhin.2016.05.012
PMID: 27346624
Abstract: Inpatients who had been in close contact with patients with influenza were given oseltamivir [75 mg capsules once daily for adults or 2 mg/kg (maximum of 75 mg) once daily for children] for three days as postexposure prophylaxis (PEP). The index patients with influenza were prescribed a neuraminidase inhibitor and were discharged immediately or transferred to isolation rooms. The protective efficacy of oseltamivir for three days was 93% overall [95% confidence interval (CI) 53-99%; P = 0.023] and 94% for influenza A (95% CI 61-99%; P = 0.017), which is comparable to that of seven- to 10-day regimens of oseltamivir as PEP.
Rights: © 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
http://creativecommons.org/licenses/by-nc-nd/4.0/
Type: article (author version)
URI: http://hdl.handle.net/2115/67230
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 石黒 信久

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