Enantioselective synthesis of beta-amino acid derivatives via nickel-promoted regioselective carboxylation of ynamides and rhodium-catalyzed asymmetric hydrogenation


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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/67579

Title:	Enantioselective synthesis of beta-amino acid derivatives via nickel-promoted regioselective carboxylation of ynamides and rhodium-catalyzed asymmetric hydrogenation
Authors:	Saito, Nozomi Browse this author →KAKEN DB
	Abdullah, Iman Browse this author
	Hayashi, Kayoko Browse this author
	Hamada, Katsuyuki Browse this author
	Koyama, Momoko Browse this author
	Sato, Yoshihiro Browse this author →KAKEN DB
Issue Date:	14-Nov-2016
Publisher:	Royal Society of Chemistry
Journal Title:	Organic & biomolecular chemistry
Volume:	14
Issue:	42
Start Page:	10080
End Page:	10089
Publisher DOI:	10.1039/c6ob01234e
PMID:	27722728
Abstract:	We succeeded in the development of a new method for enantioselective synthesis of alpha-substituted-beta-amino acid derivatives. Thus, nickel(0)-promoted carboxylation of ynamide gave the alpha-substituted-beta-aminoacrylate derivative in a highly regioselective manner. Then, rhodium-catalyzed asymmetric hydrogenation of the a-substituted beta-aminoacrylate produced the corresponding alpha-substituted beta-amino acid derivative as an optically active form.
Type:	article (author version)
URI:	http://hdl.handle.net/2115/67579
Appears in Collections:	薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 佐藤美洋

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