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Facilitation of brain mitochondrial activity by 5-aminolevulinic acid in a mouse model of Alzheimer's disease

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タイトル: Facilitation of brain mitochondrial activity by 5-aminolevulinic acid in a mouse model of Alzheimer's disease
著者: Omori, Chiori 著作を一覧する
Motodate, Rika 著作を一覧する
Shiraki, Yuzuha 著作を一覧する
Chiba, Kyoko 著作を一覧する
Sobu, Yuriko 著作を一覧する
Kimura, Ayano 著作を一覧する
Nakaya, Tadashi 著作を一覧する
Kondo, Hikaru 著作を一覧する
Kurumiya, Satoshi 著作を一覧する
Tanaka, Toru 著作を一覧する
Yamamoto, Kazuo 著作を一覧する
Nakajima, Motowo 著作を一覧する
Suzuki, Toshiharu 著作を一覧する
Hata, Saori 著作を一覧する
キーワード: 5-Aminolevulinic acid
Cytochrome c oxidase
Alzheimer's disease
発行日: 2016年 6月22日
出版者: Taylor & Francis
誌名: Nutritional neuroscience
巻: 20
号: 9
開始ページ: 538
終了ページ: 546
出版社 DOI: 10.1080/1028415X.2016.1199114
抄録: The activities of mitochondrial enzymes, which are essential for neural function, decline with age and in age-related disease. In particular, the activity of cytochrome c oxidase (COX/complex IV) decreases in patients with Alzheimer's disease (AD). COX, a mitochondrial inner membrane protein complex that contains heme, plays an essential role in the electron transport chain that generates ATP. Heme synthesis begins with 5-aminolevulinic acid (5-ALA) in mitochondria. 5-ALA synthetase is the rate-limiting enzyme in heme synthesis, suggesting that supplementation with 5-ALA might help preserve mitochondrial activity in the aged brain. We administered a diet containing 5-ALA to triple-transgenic AD (3xTg-AD) model mice for 6 months, starting at 3 months of age. COX activity and protein expression, as well as mitochondrial membrane potential, were significantly higher in brains of 5-ALA-fed mice than in controls. Synaptotagmin protein levels were also significantly higher in 5-ALA-fed mice, suggesting improved preservation of synapses. Although brain A levels tended to decrease in 5-ALA-fed mice, we observed no other significant changes in other biochemical and pathological hallmarks of AD. Nevertheless, our study suggests that daily oral administration of 5-ALA could preserve mitochondrial enzyme activities in the brains of aged individuals, thereby contributing to the preservation of neural activity.
Rights: This is an Accepted Manuscript of an article published by Taylor & Francis in Nutr. Neurosci. on 22 Jun 2016, available online:
資料タイプ: article (author version)
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 羽田 沙緒里


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