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Interaction of inhibitory and facilitatory effects of conditioning trials on long-term memory formation

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Title: Interaction of inhibitory and facilitatory effects of conditioning trials on long-term memory formation
Authors: Hosono, Shouhei Browse this author
Matsumoto, Yukihisa Browse this author
Mizunami, Makoto Browse this author →KAKEN DB
Issue Date: Dec-2016
Publisher: Cold Spring Harbor Laboratory Press
Journal Title: Learning & memory
Volume: 23
Issue: 12
Start Page: 669
End Page: 678
Publisher DOI: 10.1101/lm.043513.116
Abstract: Animals learn through experience and consolidate the memories into long-time storage. Conditioning parameters to induce protein synthesis-dependent long-term memory (LTM) have been the subject of extensive studies in many animals. Here we found a case in which a conditioning trial inhibits or facilitates LTM formation depending on the intervals from preceding trials. We studied the effects of conditioning parameters on LTM formation in olfactory conditioning of maxillary-palpi extension response with sucrose reward in the cockroach Periplaneta americana. We found, at first, that translation-and transcription- dependent LTM forms 1 h after training, the fastest so far reported in insects. Second, we observed that multipletrial training with an intertrial interval (ITI) of 20 or 30 sec, often called massed training, is more effective than spaced training for LTM formation, an observation that differs from the results of most studies in other animals. Third, we found that a conditioning trial inhibits LTM formation when the intervals from preceding trials were in the range of 10-16 min. This inhibitory effect is pairing-specific and is not due to decreased motivation for learning (overtraining effect). To our knowledge, no similar inhibition of LTM formation by a conditioning trial has been reported in any animals. We propose a model to account for the effects of trial number and ITIs on LTM formation. Olfactory conditioning in cockroaches should provide pertinent materials in which to study neuronal and molecular mechanisms underlying the inhibitory and facilitatory processes for LTM formation.
Type: article
Appears in Collections:理学院・理学研究院 (Graduate School of Science / Faculty of Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 水波 誠

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