HUSCAP logo Hokkaido Univ. logo

Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Medicine / Faculty of Medicine >
Peer-reviewed Journal Articles, etc >

Phase I study of stereotactic body radiation therapy for peripheral T2N0M0 non-small cell lung cancer (JCOG0702) : Results for the group with PTV ⩾ 100 cc

This item is licensed under: Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International

Files in This Item:
Appendix1.docxSupplementary data 124.47 kBMicrosoft Word XMLView/Open
Appendix2.pptxSupplementary data 279.95 kBMicrosoft Powerpoint XMLView/Open
RadiotherOncol122_281.pdf317.9 kBPDFView/Open
Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/68254

Title: Phase I study of stereotactic body radiation therapy for peripheral T2N0M0 non-small cell lung cancer (JCOG0702) : Results for the group with PTV ⩾ 100 cc
Other Titles: Dose escalation study of SBRT : JCOG 0702
Authors: Onimaru, Rikiya Browse this author →KAKEN DB
Onishi, Hiroshi Browse this author →KAKEN DB
Shibata, Taro Browse this author
Hiraoka, Masahiro Browse this author →KAKEN DB
Ishikura, Satoshi Browse this author
Karasawa, Katsuyuki Browse this author
Matsuo, Yukinori Browse this author →KAKEN DB
Kokubo, Masaki Browse this author →KAKEN DB
Shioyama, Yoshiyuki Browse this author →KAKEN DB
Matsushita, Haruo Browse this author →KAKEN DB
Ito, Yoshinori Browse this author
Shirato, Hiroki Browse this author →KAKEN DB
Keywords: dose escalation study
continual reassessment method
non-small cell lung cancer (NSCLC)
stereotactic body radiotherapy
SBRT
Issue Date: Feb-2017
Publisher: Elsevier
Journal Title: Radiotherapy and Oncology
Volume: 122
Issue: 2
Start Page: 281
End Page: 285
Publisher DOI: 10.1016/j.radonc.2016.11.022
PMID: 27993416
Abstract: Purpose: A dose escalation study to determine the recommended dose (RD) with stereotactic body radiation therapy (SBRT) for peripheral T2N0M0 non-small cell carcinomas (NSCLC) was conducted. The results of the group with PTV ⩾ 100 cc is reported in this paper. Materials and Methods: The continual reassessment method (CRM) was used to determine the dose level that patients should be assigned to and to estimate the maximum tolerated dose (MTD). Dose limiting toxicity (DLT) was Grade 3 or higher radiation pneumonitis (RP), and Grade 2 or higher RP was used as a surrogate DLT. The RD was equal to the MTD. The dose was prescribed at D95 of the PTV. Results: Thirteen patients were accrued. More patients should have been enrolled but we decided not to prolong the study period. No patients experienced Grade 3 RP. Two patients experienced Grade 2 RP at 50 Gy in 4 fractions. The predicted MTD was 50.2 Gy. The posterior probability of the Grade 2 RP frequency over 40% was 5.3% for the dose level of 50 Gy. The RD was determined to be 50 Gy. Conclusions: The RD was determined to be 50 Gy in 4 fractions in this population.
Rights: © 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
http://creativecommons.org/licenses/by-nc-nd/4.0/
Type: article (author version)
URI: http://hdl.handle.net/2115/68254
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 鬼丸 力也

Export metadata:

OAI-PMH ( junii2 , jpcoar )

MathJax is now OFF:


 

Feedback - Hokkaido University