| Title: | Phase I study of stereotactic body radiation therapy for peripheral T2N0M0 non-small cell lung cancer (JCOG0702) : Results for the group with PTV ⩾ 100 cc |
| Other Titles: | Dose escalation study of SBRT : JCOG 0702 |
| Authors: | Onimaru, Rikiya Browse this author →KAKEN DB |
| Onishi, Hiroshi Browse this author →KAKEN DB |
| Shibata, Taro Browse this author |
| Hiraoka, Masahiro Browse this author →KAKEN DB |
| Ishikura, Satoshi Browse this author |
| Karasawa, Katsuyuki Browse this author |
| Matsuo, Yukinori Browse this author →KAKEN DB |
| Kokubo, Masaki Browse this author →KAKEN DB |
| Shioyama, Yoshiyuki Browse this author →KAKEN DB |
| Matsushita, Haruo Browse this author →KAKEN DB |
| Ito, Yoshinori Browse this author |
| Shirato, Hiroki Browse this author →KAKEN DB |
| Keywords: | dose escalation study |
| continual reassessment method |
| non-small cell lung cancer (NSCLC) |
| stereotactic body radiotherapy |
| SBRT |
| Issue Date: | Feb-2017 |
| Publisher: | Elsevier |
| Journal Title: | Radiotherapy and Oncology |
| Volume: | 122 |
| Issue: | 2 |
| Start Page: | 281 |
| End Page: | 285 |
| Publisher DOI: | 10.1016/j.radonc.2016.11.022 |
| PMID: | 27993416 |
| Abstract: | Purpose: A dose escalation study to determine the recommended dose (RD) with stereotactic body radiation therapy (SBRT) for peripheral T2N0M0 non-small cell carcinomas (NSCLC) was conducted. The results of the group with PTV ⩾ 100 cc is reported in this paper. Materials and Methods: The continual reassessment method (CRM) was used to determine the dose level that patients should be assigned to and to estimate the maximum tolerated dose (MTD). Dose limiting toxicity (DLT) was Grade 3 or higher radiation pneumonitis (RP), and Grade 2 or higher RP was used as a surrogate DLT. The RD was equal to the MTD. The dose was prescribed at D95 of the PTV. Results: Thirteen patients were accrued. More patients should have been enrolled but we decided not to prolong the study period. No patients experienced Grade 3 RP. Two patients experienced Grade 2 RP at 50 Gy in 4 fractions. The predicted MTD was 50.2 Gy. The posterior probability of the Grade 2 RP frequency over 40% was 5.3% for the dose level of 50 Gy. The RD was determined to be 50 Gy. Conclusions: The RD was determined to be 50 Gy in 4 fractions in this population. |
| Rights: | © 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/68254 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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