Stepwise cyclopropanation on the polycyclopropanated polyketide formation in jawsamycin biosynthesis


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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/68285

Title:	Stepwise cyclopropanation on the polycyclopropanated polyketide formation in jawsamycin biosynthesis
Authors:	Hiratsuka, Tomoshige Browse this author
	Suzuki, Hideaki Browse this author
	Minami, Atsushi Browse this author
	Oikawa, Hideaki Browse this author →KAKEN DB
Issue Date:	7-Feb-2017
Publisher:	Royal Society of Chemistry
Journal Title:	Organic & biomolecular chemistry
Volume:	15
Issue:	5
Start Page:	1076
End Page:	1079
Publisher DOI:	10.1039/c6ob02675c
PMID:	28059412
Abstract:	Jawsamycin is a polyketide-nucleoside hybrid with a unique poly-cyclopropane moiety on a single polyketide chain. The unexpected isolation of cyclopropane deficient jawsamycin analogs allowed us to propose a stepwise cyclopropanation mechanism for the enzymatic synthesis of this polyketide. The concise timing of the cyclopropanation could be regulated by a delicate balance between reaction rates of the condensation and cyclopropanation reactions.
Type:	article (author version)
URI:	http://hdl.handle.net/2115/68285
Appears in Collections:	理学院・理学研究院 (Graduate School of Science / Faculty of Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 及川英秋

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