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Spatial and temporal variation at major histocompatibility complex class IIB genes in the endangered Blakiston’s fish owl

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Title: Spatial and temporal variation at major histocompatibility complex class IIB genes in the endangered Blakiston’s fish owl
Authors: Kohyama, Tetsuo I Browse this author
Omote, Keita Browse this author
Nishida, Chizuko Browse this author
Takenaka, Takeshi Browse this author
Saito, Keisuke Browse this author
Fujimoto, Satoshi Browse this author
Masuda, Ryuichi Browse this author →KAKEN DB
Keywords: Balancing selection
Bubo blakistoni
Genetic drift
MHC class IIβ
Issue Date: 25-Mar-2015
Journal Title: Zoological Letters
Volume: 1
Start Page: 13
Publisher DOI: 10.1186/s40851-015-0013-4
Abstract: Introduction Quantifying intraspecific genetic variation in functionally important genes, such as those of the major histocompatibility complex (MHC), is important in the establishment of conservation plans for endangered species. The MHC genes play a crucial role in the vertebrate immune system and generally show high levels of diversity, which is likely due to pathogen-driven balancing selection. The endangered Blakiston’s fish owl (Bubo blakistoni) has suffered marked population declines on Hokkaido Island, Japan, during the past several decades due to human-induced habitat loss and fragmentation. We investigated the spatial and temporal patterns of genetic diversity in MHC class IIβ genes in Blakiston’s fish owl, using massively parallel pyrosequencing. Results We found that the Blakiston’s fish owl genome contains at least eight MHC class IIβ loci, indicating recent gene duplications. An analysis of sequence polymorphism provided evidence that balancing selection acted in the past. The level of MHC variation, however, was low in the current fish owl populations in Hokkaido: only 19 alleles were identified from 174 individuals. We detected considerable spatial differences in MHC diversity among the geographically isolated populations. We also detected a decline of MHC diversity in some local populations during the past decades. Conclusions Our study demonstrated that the current spatial patterns of MHC variation in Blakiston’s fish owl populations have been shaped by loss of variation due to the decline and fragmentation of populations, and that the short-term effects of genetic drift have counteracted the long-term effects of balancing selection.
Type: article
Appears in Collections:理学院・理学研究院 (Graduate School of Science / Faculty of Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 増田 隆一

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