Synthesis of Fluorine-Containing 6-Arylpurine Derivatives Cp*Co(III)-Catalyzed C-H Bond Activation


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Title:	Synthesis of Fluorine-Containing 6-Arylpurine Derivatives Cp*Co(III)-Catalyzed C-H Bond Activation
Authors:	Murakami, Nanami Browse this author
	Yoshida, Misaki Browse this author
	Yoshino, Tatsuhiko Browse this author →KAKEN DB
	Matsunaga, Shigeki Browse this author →KAKEN DB
Keywords:	C-H bond functionalization
	6-arylpurine
	cobalt catalysis
	gem-difluoroalkene
	allyl fluoride
Issue Date:	Jan-2018
Publisher:	The Pharmaceutical Society of Japan
Journal Title:	Chemical & pharmaceutical bulletin
Volume:	66
Issue:	1
Start Page:	51
End Page:	54
Publisher DOI:	10.1248/cpb.c17-00797
PMID:	29311512
Abstract:	CpCo(III)-catalyzed (Cp=pentamethylcyclopentadienyl) C-H bond functionalization of 6-arylpurines using gem-difluoroalkenes and allyl fluorides is described. The reaction with gem-difluoroalkenes afforded monofluoroalkenes with high (Z)-selectivity, while the reaction with allyl fluorides led to C-H allylation in moderate (Z)-selectivity. Both reactions proceeded using a user-friendly single-component catalyst [Cp*Co(CH3CN)(3)](SbF6)(2) in fluorinated alcohol solvents without any additives. Robustness was also demonstrated by a preparative-scale reaction under air.
Type:	article
URI:	http://hdl.handle.net/2115/68309
Appears in Collections:	薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 松永茂樹

OAI-PMH ( junii2 , jpcoar_1.0 )

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