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Synthesis of Fluorine-Containing 6-Arylpurine Derivatives Cp*Co(III)-Catalyzed C-H Bond Activation

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Title: Synthesis of Fluorine-Containing 6-Arylpurine Derivatives Cp*Co(III)-Catalyzed C-H Bond Activation
Authors: Murakami, Nanami Browse this author
Yoshida, Misaki Browse this author
Yoshino, Tatsuhiko Browse this author →KAKEN DB
Matsunaga, Shigeki Browse this author →KAKEN DB
Keywords: C-H bond functionalization
6-arylpurine
cobalt catalysis
gem-difluoroalkene
allyl fluoride
Issue Date: Jan-2018
Publisher: The Pharmaceutical Society of Japan
Journal Title: Chemical & pharmaceutical bulletin
Volume: 66
Issue: 1
Start Page: 51
End Page: 54
Publisher DOI: 10.1248/cpb.c17-00797
PMID: 29311512
Abstract: Cp*Co(III)-catalyzed (Cp*=pentamethylcyclopentadienyl) C-H bond functionalization of 6-arylpurines using gem-difluoroalkenes and allyl fluorides is described. The reaction with gem-difluoroalkenes afforded monofluoroalkenes with high (Z)-selectivity, while the reaction with allyl fluorides led to C-H allylation in moderate (Z)-selectivity. Both reactions proceeded using a user-friendly single-component catalyst [Cp*Co(CH3CN)(3)](SbF6)(2) in fluorinated alcohol solvents without any additives. Robustness was also demonstrated by a preparative-scale reaction under air.
Type: article
URI: http://hdl.handle.net/2115/68309
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 松永 茂樹

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