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Primary malignant melanoma of the esophagus treated with subtotal esophagectomy : a case report

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Title: Primary malignant melanoma of the esophagus treated with subtotal esophagectomy : a case report
Authors: Kuwabara, Shota Browse this author
Ebihara, Yuma Browse this author →KAKEN DB
Nakanishi, Yoshitsugu Browse this author
Asano, Toshimichi Browse this author
Noji, Takehiro Browse this author →KAKEN DB
Kurashima, Yo Browse this author →KAKEN DB
Murakami, Soichi Browse this author
Nakamura, Toru Browse this author →KAKEN DB
Tsuchikawa, Takahiro Browse this author →KAKEN DB
Okamura, Keisuke Browse this author
Shichinohe, Toshiaki Browse this author →KAKEN DB
Hirano, Satoshi Browse this author →KAKEN DB
Keywords: Esophagus
Melanoma
Pathology
Treatment
Prognosis
Issue Date: 2-Dec-2017
Publisher: BioMed Central
Journal Title: BMC surgery
Volume: 17
Start Page: 122
Publisher DOI: 10.1186/s12893-017-0326-7
Abstract: Background: Primary malignant melanoma of the esophagus (PMME) is a rare disease with a poor prognosis. There are few reports of early-stage cases in which tumor invasion reached the lamina propria or muscularis mucosae, as in the present case. A standard treatment for early-stage PMME has not yet been established. The present study aimed to summarize previous reports and to discuss the indications for surgical treatment of early-stage primary malignant melanoma of the esophagus. Case presentation: A 70-year-old woman with PMME was referred to our hospital. She underwent thoracoscopic and laparoscopic subtotal esophagectomy with lymphadenectomy. The resected specimen showed melanocytosis and junctional activity. Melanoma-specific antigens melan-A, S-100, and HMB45 were detected by immunohistochemical staining. The pathological diagnosis was pT1a-MM, pN0, pM0, and pStage IA. She remains alive without evidence of recurrence 39 months later. Conclusion: Subtotal esophagectomy with regional radical lymphadenectomy could be recommended to patients with early-stage primary malignant melanoma of the esophagus, and curative surgical resection could improve their prognosis.
Rights: http://creativecommons.org/licenses/by/4.0/
Type: article
URI: http://hdl.handle.net/2115/68335
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 海老原 裕磨

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