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The localization of GATA2 in the nuclear and cytoplasmic regions of ovine conceptuses

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Title: The localization of GATA2 in the nuclear and cytoplasmic regions of ovine conceptuses
Authors: Bai, Hanako Browse this author
Sakurai, Toshihiro Browse this author
Bai, Rulan Browse this author
Godkin, James D. Browse this author
Imakawa, Kazuhiko Browse this author
Keywords: GATA2
ovine conceptuses
Issue Date: Dec-2014
Journal Title: Animal Science Journal
Volume: 85
Issue: 12
Start Page: 981
End Page: 985
Publisher DOI: 10.1111/asj.12267
Abstract: Abstract:GATA transcription factors are emerging as critical regulators in trophoblast development and its gene regulation. The purpose of this study was to examine the expression and cellular localization of GATA2 in ovine conceptuses during the peri-implantation period. In Western blot analyses, GATA2 proteins were found in days 15, 17 and 21 ovine conceptuses (day 0 = day of estrus). Using immunohistochemistry and immunofluorescence analyses, we found that GATA2 was localized in days 15, 17 and 21 ovine conceptuses, and more importantly, GATA2 protein was detected in both nuclear and cytoplasmic regions of the trophectoderm. To our knowledge, the present study is the first to demonstrate that GATA2 is localized in two cellular compartments of the trophectoderm in ovine and many other mammalian species, and suggests that the difference in GATA2 location plays a role in the regulation of down-stream genes during the early pregnancy period.
Rights: © 2014 Japanese Society of Animal Science., This is the peer reviewed version of the following article: [Animal Science Journal; 85(12): pp981-985, 2014], which has been published in final form at [10.1111/asj.12267]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Type: article (author version)
Appears in Collections:農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 唄 花子

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