| Title: | The effect of duration of illness and antipsychotics on subcortical volumes in schizophrenia : Analysis of 778 subjects |
| Authors: | Hashimoto, Naoki Browse this author |
| Ito, Yoichi M. Browse this author →KAKEN DB |
| Okada, Naohiro Browse this author |
| Yamamori, Hidenaga Browse this author |
| Yasuda, Yuka Browse this author |
| Fujimoto, Michiko Browse this author |
| Kudo, Noriko Browse this author |
| Takemura, Ariyoshi Browse this author |
| Son, Shuraku Browse this author |
| Narita, Hisashi Browse this author |
| Yamamoto, Maeri Browse this author |
| Tha, Khin Khin Browse this author →KAKEN DB |
| Katsuki, Asuka Browse this author |
| Ohi, Kazutaka Browse this author |
| Yamashita, Fumio Browse this author |
| Koike, Shinsuke Browse this author |
| Takahashi, Tsutomu Browse this author |
| Nemoto, Kiyotaka Browse this author |
| Fukunaga, Masaki Browse this author |
| Onitsuka, Toshiaki Browse this author |
| Watanabe, Yoshiyuki Browse this author |
| Yamasue, Hidenori Browse this author |
| Suzuki, Michio Browse this author |
| Kasai, Kiyoto Browse this author |
| Kusumi, Ichiro Browse this author →KAKEN DB |
| Hashimoto, Ryota Browse this author |
| Keywords: | Schizophrenia |
| MRI |
| Globus pallidus |
| Hippocampus |
| Antipsychotic |
| Duration of illness |
| Issue Date: | 2018 |
| Publisher: | Elsevier |
| Journal Title: | NeuroImage : Clinical |
| Volume: | 17 |
| Start Page: | 563 |
| End Page: | 569 |
| Publisher DOI: | 10.1016/j.nicl.2017.11.004 |
| Abstract: | Background: The effect of duration of illness and antipsychotic medication on the volumes of subcortical structures in schizophrenia is inconsistent among previous reports. We implemented a large sample analysis utilizing clinical data from 11 institutions in a previous meta-analysis. Methods: Imaging and clinical data of 778 schizophrenia subjects were taken from a prospective meta-analysis conducted by the COCORO consortium in Japan. The effect of duration of illness and daily dose and type of antipsychotics were assessed using the linear mixed effect model where the volumes of subcortical structures computed by FreeSurfer were used as a dependent variable and age, sex, duration of illness, daily dose of antipsychotics and intracranial volume were used as independent variables, and the type of protocol was incorporated as a random effect for intercept. The statistical significance of fixed-effect of dependent variable was assessed. Results: Daily dose of antipsychotics was positively associated with left globus pallidus volume and negatively associated with right hippocampus. It was also positively associated with laterality index of globus pallidus. Duration of illness was positively associated with bilateral globus pallidus volumes. Type of antipsychotics did not have any effect on the subcortical volumes. Discussion: A large sample size, uniform data collection methodology and robust statistical analysis are strengths of the current study. This result suggests that we need special attention to discuss about relationship between subcortical regional brain volumes and pathophysiology of schizophrenia because regional brain volumes may be affected by antipsychotic medication. |
| Rights: | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/70164 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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