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The effect of duration of illness and antipsychotics on subcortical volumes in schizophrenia : Analysis of 778 subjects

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Title: The effect of duration of illness and antipsychotics on subcortical volumes in schizophrenia : Analysis of 778 subjects
Authors: Hashimoto, Naoki Browse this author
Ito, Yoichi M. Browse this author →KAKEN DB
Okada, Naohiro Browse this author
Yamamori, Hidenaga Browse this author
Yasuda, Yuka Browse this author
Fujimoto, Michiko Browse this author
Kudo, Noriko Browse this author
Takemura, Ariyoshi Browse this author
Son, Shuraku Browse this author
Narita, Hisashi Browse this author
Yamamoto, Maeri Browse this author
Tha, Khin Khin Browse this author →KAKEN DB
Katsuki, Asuka Browse this author
Ohi, Kazutaka Browse this author
Yamashita, Fumio Browse this author
Koike, Shinsuke Browse this author
Takahashi, Tsutomu Browse this author
Nemoto, Kiyotaka Browse this author
Fukunaga, Masaki Browse this author
Onitsuka, Toshiaki Browse this author
Watanabe, Yoshiyuki Browse this author
Yamasue, Hidenori Browse this author
Suzuki, Michio Browse this author
Kasai, Kiyoto Browse this author
Kusumi, Ichiro Browse this author →KAKEN DB
Hashimoto, Ryota Browse this author
Keywords: Schizophrenia
Globus pallidus
Duration of illness
Issue Date: 2018
Publisher: Elsevier
Journal Title: NeuroImage : Clinical
Volume: 17
Start Page: 563
End Page: 569
Publisher DOI: 10.1016/j.nicl.2017.11.004
Abstract: Background: The effect of duration of illness and antipsychotic medication on the volumes of subcortical structures in schizophrenia is inconsistent among previous reports. We implemented a large sample analysis utilizing clinical data from 11 institutions in a previous meta-analysis. Methods: Imaging and clinical data of 778 schizophrenia subjects were taken from a prospective meta-analysis conducted by the COCORO consortium in Japan. The effect of duration of illness and daily dose and type of antipsychotics were assessed using the linear mixed effect model where the volumes of subcortical structures computed by FreeSurfer were used as a dependent variable and age, sex, duration of illness, daily dose of antipsychotics and intracranial volume were used as independent variables, and the type of protocol was incorporated as a random effect for intercept. The statistical significance of fixed-effect of dependent variable was assessed. Results: Daily dose of antipsychotics was positively associated with left globus pallidus volume and negatively associated with right hippocampus. It was also positively associated with laterality index of globus pallidus. Duration of illness was positively associated with bilateral globus pallidus volumes. Type of antipsychotics did not have any effect on the subcortical volumes. Discussion: A large sample size, uniform data collection methodology and robust statistical analysis are strengths of the current study. This result suggests that we need special attention to discuss about relationship between subcortical regional brain volumes and pathophysiology of schizophrenia because regional brain volumes may be affected by antipsychotic medication.
Type: article
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 橋本 直樹

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